Biomarkers in Ulcerative Colitis

Publication Date: February 21, 2023

Key Points

Key Points

  • There is an important need for understanding how noninvasive biomarkers may serve as accurate and reliable surrogates for endoscopic assessment of inflammation.
  • Commonly available biomarkers are well-established as surrogate tests for endoscopic assessment of disease and in longitudinal monitoring of patients with an established diagnosis of ulcerative colitis (UC).
  • This guideline focuses on the following biomarkers: serum C-reactive protein (CRP), fecal calprotectin, and fecal lactoferrin.

Diagnosis

Diagnosi...

...mary of Recommendations

...nts With Ulcerative Colitis in Sympto...

...ents with UC in symptomatic remission, the AGA...

...calprotectin...

normal fecal lactoferrin (C, L)6...

...L)Implementation consideration: Normal CRP ma...

In patients with UC in symptomatic...

...Symptomatically Active Ulcerative Colitis...

...ients with symptomatically active...

...ecal calprotectin >150 μg/g (C, L...

...fecal lactoferrin (C, VL)6...

...ted CRP (C, M)620...

...ts with UC with mild symptoms, with elevated stool...

...tients with UC with mild symptoms, with normal sto...

...Strategies for Ulcerative Colitis...

...ents with UC, the AGA makes no reco...


...y Considerations When Using Biomarkers fo...


Treatment

Treatmen...

...onsequences of Diagnostic Test Results on Patien...