Contemporary Management Of Uterine Clear Cell Carcinoma

Publication Date: November 1, 2019

Conclusions

1. UCCC has a higher propensity for extrauterine spread and warrants extended or comprehensive surgical staging, although sentinel lymph node dissection may be a reasonable alternative to complete lymphadenectomy.
2. UCCC is less responsive to chemotherapy when compared to other types of endometrial cancer.
3. We recommend consideration of chemotherapy but also recommend development of clinical trials to further evaluate the role of chemotherapy for early stage UCCC. A.B. Olawaiye, C.A. Leath III / Gynecologic Oncology 155 (2019) 365e373 371
4. Vaginal cuff brachytherapy may offer a benefit in outcomes for women with early stage UCCC.
5. Patients with advanced stage UCCC should be offered adjuvant therapy, although evidence for UCCC-specific adjuvant therapy is lacking.
6. In spite of a higher probability of receiving adjuvant therapy than other types of uterine cancer, both PFS and OS for UCCC appears to be inferior thus further solidifying UCCC as an aggressive histology with unique and largely unknown profile.
7. Future clinical trials should continue to allow UCCC enrollment with this and other high risk histologies utilized as a stratification variable.

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Overview

Title

Contemporary Management Of Uterine Clear Cell Carcinoma

Authoring Organization

Publication Month/Year

November 1, 2019

Document Type

Guideline

External Publication Status

Published

Country of Publication

US

Document Objectives

This SGO review is updated with all relevant, published information since 2009 considered clinically important for management of uterine clear cell carcinoma. 

Target Patient Population

Patients with uterine clear cell carcinoma

Inclusion Criteria

Female, Adolescent, Adult, Older adult

Health Care Settings

Ambulatory, Hospice, Hospital, Operating and recovery room, Outpatient

Intended Users

Nurse, nurse practitioner, physician, physician assistant

Scope

Assessment and screening, Diagnosis, Management, Treatment

Diseases/Conditions (MeSH)

D002583 - Uterine Cervical Neoplasms, D018262 - Adenocarcinoma, Clear Cell, D018227 - Sarcoma, Clear Cell, D014594 - Uterine Neoplasms

Keywords

oncology, uterine neoplasms, clear cell carcinoma