Contemporary Management Of Uterine Clear Cell Carcinoma

Publication Date: November 1, 2019
Last Updated: March 14, 2022


1. UCCC has a higher propensity for extrauterine spread and warrants extended or comprehensive surgical staging, although sentinel lymph node dissection may be a reasonable alternative to complete lymphadenectomy.
2. UCCC is less responsive to chemotherapy when compared to other types of endometrial cancer.
3. We recommend consideration of chemotherapy but also recommend development of clinical trials to further evaluate the role of chemotherapy for early stage UCCC. A.B. Olawaiye, C.A. Leath III / Gynecologic Oncology 155 (2019) 365e373 371
4. Vaginal cuff brachytherapy may offer a benefit in outcomes for women with early stage UCCC.
5. Patients with advanced stage UCCC should be offered adjuvant therapy, although evidence for UCCC-specific adjuvant therapy is lacking.
6. In spite of a higher probability of receiving adjuvant therapy than other types of uterine cancer, both PFS and OS for UCCC appears to be inferior thus further solidifying UCCC as an aggressive histology with unique and largely unknown profile.
7. Future clinical trials should continue to allow UCCC enrollment with this and other high risk histologies utilized as a stratification variable.

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Contemporary Management Of Uterine Clear Cell Carcinoma

Authoring Organization

Publication Month/Year

November 1, 2019

Last Updated Month/Year

March 16, 2023

Document Type


External Publication Status


Country of Publication


Document Objectives

This SGO review is updated with all relevant, published information since 2009 considered clinically important for management of uterine clear cell carcinoma. 

Target Patient Population

Patients with uterine clear cell carcinoma

Inclusion Criteria

Female, Adolescent, Adult, Older adult

Health Care Settings

Ambulatory, Hospice, Hospital, Operating and recovery room, Outpatient

Intended Users

Nurse, nurse practitioner, physician, physician assistant


Assessment and screening, Diagnosis, Management, Treatment

Diseases/Conditions (MeSH)

D002583 - Uterine Cervical Neoplasms, D018262 - Adenocarcinoma, Clear Cell, D018227 - Sarcoma, Clear Cell, D014594 - Uterine Neoplasms


oncology, uterine neoplasms, clear cell carcinoma