Management of Infants and Neonates with Tetralogy of Fallot

Authoring Organization

Publication Month/Year

October 26, 2022

Last Updated Month/Year

July 3, 2023

Document Type


Country of Publication


Document Objectives

Despite decades of experience, aspects of the management of tetralogy of Fallot with pulmonary stenosis (TOF) remain controversial. Practitioners must consider newer, evolving treatment strategies with limited data to guide decision making. Therefore, the TOF Clinical Practice Standards Committee was commissioned by the American Association for Thoracic Surgery to provide a framework on this topic, focused on timing and types of interventions, management of high-risk patients, technical considerations during interventions, and best practices for assessment of outcomes of the interventions. In addition, the group was tasked with identifying pertinent research questions for future investigations. It is recognized that variability in institutional experience could influence the application of this framework to clinical practice.

Inclusion Criteria

Male, Female, Infant

Health Care Settings

Hospital, Operating and recovery room

Intended Users

Nurse, nurse practitioner, physician, physician assistant


Treatment, Management

Diseases/Conditions (MeSH)

D013771 - Tetralogy of Fallot


neonates, pulmonary valve reconstruction, tetralogy of Fallot

Source Citation

Expert Consensus Panel:; Miller JR, Stephens EH, Goldstone AB, Glatz AC, Kane L, Van Arsdell GS, Stellin G, Barron DJ, d'Udekem Y, Benson L, Quintessenza J, Ohye RG, Talwar S, Fremes SE, Emani SM, Eghtesady P. The American Association for Thoracic Surgery (AATS) 2022 Expert Consensus Document: Management of infants and neonates with tetralogy of Fallot. J Thorac Cardiovasc Surg. 2023 Jan;165(1):221-250. doi: 10.1016/j.jtcvs.2022.07.025. Epub 2022 Oct 26. PMID: 36522807.