Neuroprognostication in Comatose Adult Survivors of Cardiac Arrest

Authoring Organization

Publication Month/Year

March 22, 2023

Last Updated Month/Year

September 11, 2023

Document Type


Country of Publication


Document Objectives

Among cardiac arrest survivors, about half remain comatose 72 h following return of spontaneous circulation (ROSC). Prognostication of poor neurological outcome in this population may result in withdrawal of life-sustaining therapy and death. The objective of this article is to provide recommendations on the reliability of select clinical predictors that serve as the basis of neuroprognostication and provide guidance to clinicians counseling surrogates of comatose cardiac arrest survivors.

Inclusion Criteria

Male, Female, Adult, Older adult

Health Care Settings

Hospital, Outpatient

Intended Users

Nurse, nurse practitioner, physician, physician assistant


Management, Rehabilitation


cardiac arrest, coma, neuroprognostication, comatose

Source Citation

Rajajee V, Muehlschlegel S, Wartenberg KE, Alexander SA, Busl KM, Chou SHY, Creutzfeldt CJ, Fontaine GV, Fried H, Hocker SE, Hwang DY, Kim KS, Madzar D, Mahanes D, Mainali S, Meixensberger J, Montellano F, Sakowitz OW, Weimar C, Westermaier T, Varelas PN. Guidelines for Neuroprognostication in Comatose Adult Survivors of Cardiac Arrest. Neurocrit Care. 2023 Jun;38(3):533-563. doi: 10.1007/s12028-023-01688-3. Epub 2023 Mar 22. PMID: 36949360; PMCID: PMC10241762.

Supplemental Methodology Resources

Data Supplement