Treatment

Document Overview

Design and created by Guideline Central in participation with the American Society of Clinical Oncology.

Treatment of Locally Advanced Esophageal Carcinoma

American Society of Clinical Oncology

Publication Date: Jul 28, 2021

Page Last Updated: May 5, 2026

Grading Table

Type		Benefit/harm		Evidence Quality		Strength of Recommendation
EB	Evidence-based	B	Benefits outweigh harms	H	High	Strong
CB	Consensus-based	H	Harms outweigh benefits	I	Intermediate	Moderate
IC	Informal consensus	B/H	Relative balance of benefits and harms	L	Low	Weak
IC	Informal consensus	U	Unknown	Ins	Insufficient	Weak

Document Overview

Document Title: Treatment of Locally Advanced Esophageal Carcinoma

Authoring Society: American Society of Clinical Oncology

Document Publication Date: Jul 28, 2021

Page Last Reviewed/Updated: May 5, 2026

Document Type: Guideline

Country of Publication: United States

Full Text Freely Available: Yes

Full Text Guideline: ascopubs.org/doi/full/10.1200/JCO.21.01831

Source Citation: Manish A. Shah, MD; Erin B. Kennedy, MHSc; Dan Catenacci, MD; et al. Treatment of Locally Advanced Esophageal Carcinoma: ASCO Guideline. J Clin Oncol. 2021 July 28 doi: 10.1200/JCO.21.01831

Manish A. Shah, MD; Erin B. Kennedy, MHSc; Dan Catenacci, MD; Dana C. Deighton; Karyn A. Goodman, MD; Narinder K. Malhotra, MD; Christopher Willett, MD; Brendon Stiles, MD; Prateek Sharma, MD; Laura Tang, MD PhD; Bas P.L. Wijnhoven, MD, PhD; Wayne Hofstetter, MD. Treatment of Locally Advanced Esophageal Carcinoma: ASCO Guideline. J Clin Oncol. 2020 June 22 doi: 10.1200/JCO.20.00866

Supplemental Implementation Resources

Document Scope, Criteria, and Use Cases

Document Objectives: To develop an evidence-based clinical practice guideline to assist in clinical decision making for patients with locally advanced esophageal cancer.

Scope: Management, Treatment

Keywords: esophageal adenocarcinoma, esophageal carcinoma, squamous cell carcinoma

Inclusion Criteria: Male, Female, Adolescent, Adult, Older Adult

Health Care Settings: Hospital, Outpatient, Radiology Services

Intended Users: Nurse, Nurse Practitioner, Physician, Physician Assistant

Recommendation Development Processes & Methodology

Supplemental Methodology Resource: Data Supplement

Number of Source Documents: 64

Literature Search Start Date: Friday, January 1, 1999

Literature Search End Date: Tuesday, December 31, 2019

Includes peer/external review process?: Yes

Includes public comment process?: Yes

Methodologist involvement?: Yes

Patient involvement?: Yes

Includes multi-disciplinary group?: Yes

Includes systematic review?: Yes

Grades quality of strength of evidence?: Yes

Grades quality of strength of recommendation?: Yes

Discloses funding source?: Yes

Discloses conflicts of interest?: Yes

Includes benefits/harms analysis with recommendations?: Yes

Identifies study selection process?: Yes

Identifies study selection criteria?: Yes

Identifies methods used to evaluate and analyze the evidence?: Yes

Identifies key questions addressed by the systematic review?: Yes

Identifies search strategy?: Yes

Treatment of Locally Advanced Esophageal Carcinoma

Treatment

Practice Statement

Practice Statement

ASCO Recommendation Update – August 2021

Grading Table

Document Overview

Supplemental Implementation Resources

Document Scope, Criteria, and Use Cases

Recommendation Development Processes & Methodology