Long-Term Noninvasive Ventilation in Chronic Stable Hypercapnic Chronic Obstructive Pulmonary Disease

Publication Date: August 15, 2020

Key Points

Key Points

  • Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality in the world and is the fourth leading cause of death in the United States.
  • To date, the only therapeutic interventions known to reduce mortality in COPD are smoking cessation and long-term treatment with continuous supplemental oxygen for patients who have severe hypoxemia at rest.
  • Recently, interest in the use of noninvasive ventilation (NIV) in chronic hypercapnic COPD has been renewed with studies of so-called “high-intensity” NIV, which refers to inspiratory pressures higher than those used in most previous randomized controlled trials (RCTs) as well as controlled ventilation with higher-than-baseline respiratory rates to maximally reduce the PaCO2.

Treatment

...atment...

...ents with chronic (FEV1/FVC < 0.70 and re...


...uggests the use of nocturnal noninvasive ven...


...S suggests that patients with chronic stable h...


...ts NOT initiating long-term NIV during an adm...


...s NOT using an in-laboratory overnight...


...ests NIV with targeted normalization...