Title
Estrogen and Progesterone Receptor Testing in Breast Cancer
Authoring Organizations
Publication Month/Year
January 13, 2020
Last Updated Month/Year
October 1, 2024
Supplemental Implementation Tools
Document Type
Guideline
External Publication Status
Published
Country of Publication
US
Document Objectives
To update key recommendations of the American Society of Clinical Oncology/College of American Pathologists estrogen (ER) and progesterone receptor (PgR) testing in breast cancer guideline
Target Patient Population
Patients with breast cancer.
Target Provider Population
Medical oncologists, pathologists, surgeons, radiation oncologists
PICO Questions
What additional strategies can promote optimal performance, interpretation, and reporting of immunohistochemistry (IHC) assays, particularly in cases with low estrogen receptor (ER) expression?
Are other ER expression assays acceptable for identifying patients likely to benefit from endocrine therapy?
What are the optimum quality assurance (QA), tissue handling, scoring system, and reporting for determining potential benefit from endocrine therapy?
Should ductal carcinoma in situ (DCIS) be routinely tested for hormone receptors?
Inclusion Criteria
Female, Adult, Older adult
Health Care Settings
Ambulatory, Hospital, Laboratory services, Outpatient
Intended Users
Nurse, nurse practitioner, physician, physician assistant
Scope
Diagnosis, Assessment and screening
Diseases/Conditions (MeSH)
D011960 - Receptors, Estrogen, D011374 - Progesterone, D011980 - Receptors, Progesterone
Keywords
breast cancer, estrogen, progesterone, cancer, estrogen receptor, progesterone receptors, testing, Breast Cancer
Source Citation
Allison KH, Hammond MEH, Dowsett M, McKernin SE, Carey LA, Fitzgibbons PL, Hayes DF, Lakhani SR, Chavez-MacGregor M, Perlmutter J, Perou CM, Regan MM, Rimm DL, Symmans WF, Torlakovic EE, Varella L, Viale G, Weisberg TF, McShane LM, Wolff AC. Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO/CAP Guideline Update. J Clin Oncol. 2020 Apr 20;38(12):1346-1366. doi: 10.1200/JCO.19.02309. Epub 2020 Jan 13. PMID: 31928404.