Treatment of Antimicrobial Resistant Gram-Negative Infections

Publication Date: June 7, 2023
Last Updated: January 19, 2024

Recommendations

Extended-Spectrum β-Lactamase-Producing Enterobacterales

Nitrofurantoin and TMP-SMX are preferred treatment options for uncomplicated cystitis caused by ESBL-E. Ciprofloxacin, levofloxacin, and carbapenems are alternative agents for uncomplicated cystitis caused by ESBL-E. Although effective, their use is discouraged when nitrofurantoin or TMP-SMX are active. Single dose aminoglycosides and oral fosfomycin (for E. coli only) are also alternative treatments for uncomplicated cystitis caused by ESBL-E.
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Overview

Title

Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections

Authoring Organization