Management of Alloimmunization During Pregnancy

Publication Date: March 1, 2018

Recommendations

In a center with trained personnel and when the fetus is at an appropriate gestational age, Doppler measurement of peak systolic velocity in the fetal middle cerebral artery is an appropriate noninvasive means to monitor pregnancies complicated by red cell alloimmunization. (A)
574

The initial management of a pregnancy involving an alloimmunized patient is determination of the paternal erythrocyte antigen status. (A)
574

Serial titers are not useful for monitoring fetal status when the mother has had a previously affected fetus or neonate. (A)
574

Antibody titers are not appropriate for monitoring Kell-sensitized patients because Kell antibodies do not correlate with fetal status. (A)
574

Anti-D immune globulin is indicated only in Rh-negative women who are not previously sensitized to D. (A)
574

Recommendation Grading

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Overview

Title

Management of Alloimmunization During Pregnancy

Authoring Organization

Publication Month/Year

March 1, 2018

Document Type

Consensus

External Publication Status

Published

Country of Publication

US

Inclusion Criteria

Female, Adolescent, Adult

Health Care Settings

Ambulatory

Intended Users

Physician, nurse midwife, nurse, nurse practitioner, physician assistant

Scope

Management

Diseases/Conditions (MeSH)

D011250 - Pregnancy Complications, Hematologic, D011248 - Pregnancy Complications, D000078422 - Allogeneic Cells, D011259 - Pregnancy Tests, Immunologic, D011252 - Pregnancy Complications, Neoplastic

Keywords

Alloimmunization, maternal antibodies