Neural tube defects

Publication Date: December 1, 2017
Last Updated: March 14, 2022

Summary of Recommendations

The following recommendations are based on good and consistent scientific evidence.

  • All women planning a pregnancy or capable of becoming pregnant should take 400 micrograms of folic acid supplementation daily. Supplementation should begin at least 1 month before pregnancy and continue through the first 12 weeks of pregnancy.
  • Women at high risk of NTDs should take 4 mg (4,000 micrograms) of folic acid daily. The daily supplement should be initiated 3 months before pregnancy and continued until 12 weeks of gestational age.



Neural Tube Defects

Authoring Organization