Immunotherapy for the Treatment of Lymphoma

For the first-line therapy of stage I–II (favorable or unfavorable risk) cHL, there was consensus that patients should receive ABVD.

For the first-line therapy of stage III–IV cHL, the panel did not reach consensus on a single preferred regimen. Options for treatment include ABVD and A-AVD.

For the second-line treatment of cHL, there was consensus that patients should receive salvage chemotherapy or immunotherapy, and should receive autoSCT, if eligible. Treatment options for pre-autoSCT chemotherapy or immunotherapy include BV+bendamustine, ifosfamide+carboplatin+etoposide (ICE), BV+nivolumab, or BV monotherapy. The panel noted that BV is FDA-approved for consolidation treatment following autoSCT, but that the trial supporting this data only examined patients who were BV-naïve, and that BV consolidation in patients who have previously received BV is still investigational.

For the third-line treatment of cHL, the panel did not reach consensus on a single preferred regimen. Options for treatment include salvage chemotherapy or immunotherapy+autoSCT (if transplant-eligible), PD-1 inhibitor therapy, or BV, depending on prior therapies received and patient status.