Optimal Timing of Elective Hip or Knee Arthroplasty for Patients with Symptomatic Moderate to Severe Osteoarthritis or Advanced Symptomatic Osteonecrosis with Secondary Arthritis for Whom Nonoperative Therapy is Ineffective

For patients with radiographically moderate to severe OA or ON of the hip or knee using standard radiographic grading such as Kellgren-Lawrence or Tonnis, and moderate to severe pain or loss of function who have been indicated for elective total joint arthroplasty (TJA) through a shared decision-making process with their physician and have completed one or more trials of appropriate nonoperative therapy.