Management of Endocarditis

Authoring Organization

Publication Month/Year

August 25, 2023

Last Updated Month/Year

August 29, 2023

Supplemental Implementation Tools

Document Type


Country of Publication


Document Objectives

The current guidelines have been developed to support healthcare professionals with the diagnosis and management of patients with infective endocarditis, an infrequent but oftentimes fatal disease that can present with multiple different clinical scenarios. The last version of the ESC Infective Endocarditis Guidelines was published in 2015. Since then there have been multiple developments in the care of patients with infective endocarditis including refinements of the indications for antibiotic prophylaxis, improvements in diagnostic capabilities, establishment of Endocarditis Teams and Heart Valve Centers, identification of patients eligible for outpatient antibiotic therapy, diagnosis and risk-stratification of patients suffering complications of endocarditis (in particular, stroke), management of patients with transcatheter heart valve- and cardiac implantable electronic device-associated infective endocarditis, and patient-centered care during the acute and follow up phases of this challenging disease. In addition, the 2023 version of the Guidelines includes a new diagnostic algorithm, which will be particularly helpful in correctly classifying patients. The current document should serve as a guide for clinicians involved in the diagnosis and management of infective endocarditis patients and should lead to improved outcomes for this serious disease.    

Inclusion Criteria

Male, Female, Adult, Older adult

Health Care Settings

Ambulatory, Hospital, Outpatient

Intended Users

Nurse, nurse practitioner, physician, physician assistant


Diagnosis, Assessment and screening, Treatment, Management

Diseases/Conditions (MeSH)

D004696 - Endocarditis


endocarditis, Infective Endocarditis

Source Citation

Victoria Delgado and others, 2023 ESC Guidelines for the management of endocarditis: Developed by the task force on the management of endocarditis of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS) and the European Association of Nuclear Medicine (EANM)European Heart Journal, 2023;, ehad193, https://doi.org/10.1093/eurheartj/ehad193