Use of Prolonged-Infusion Beta-Lactam Antibiotics

Preclinical targets for reductions in CFU are 40%–70% fT>MIC for SI and up to 4-h EI, and 100% fT>MIC with concentrations that exceed up to four to eight times free drug over the steady-state concentration (fCss) for CI. No absolute target guarantees suppression of resistance but exceeding the MIC by four to six times may minimize resistance. (U, U)