Microbiological Laboratory Testing in the Diagnosis of Fungal Infections in Pulmonary and Critical Care Practice

Publication Date: September 1, 2019

Key Points

Key Points

  • The rising prevalence of fungal infections is likely related to several factors, including an ever-growing population of susceptible patients.
  • Furthermore, endemic mycoses continue to pose a threat to both immunocompetent and immunosuppressed individuals.
  • Recent advances in laboratory diagnostics have evolved to assist the diagnosis of pulmonary fungal infections.
  • These guidelines focus on the use of galactomannan (GM) antigen and PCR testing in the diagnosis of invasive pulmonary aspergillosis (IPA), (1➝3)-β-D-glucan (BDG) assays or invasive candidiasis (IC), and the use of antigen and antibody testing in the diagnosis of endemic mycoses.

Diagnosis

...Diagnosis...

...Table 2. Recommendati...

...Invasive fu...

...ith severe immune compromise, such...

...pected of invasive fungal diseases, including...

...Invasive pulmonary asperg...

In patients with severe immune compr...

...patients with severe immune compr...

...n patients with severe immune compromis...

...Candidia...

...l patients in whom there is clinical concern fo...

...Histopl...

The ATS recommends the use of Histoplasma a...

...TS suggests the use of Histoplasma serologies...

...Blastomycosis...

...patients with appropriate geographic expos...

...with suspected blastomycosis, the A...

...patients with suspected blastomycosis, part...

...Coccidioidomycosis...

In patients with appropriate geographic ex...

...with suspected coccidioidomycosis, particular...

...atients with suspected community acquir...