Treatment of Drug-Resistant Tuberculosis
Key Points
Key Points
MDR-TB is defined specifically as resistance to at least isoniazid and rifampin, the two most important first-line drugs.
The guideline is intended for settings in which treatment is individualized and where mycobacterial cultures, molecular (genotypic) and culture-based (phenotypic) drug susceptibility tests (DSTs), and radiographic facilities are available.
Treatment success was most likely with regimens for MDR-TB containing 5 effective drugs in the intensive phase. Mortality was also significantly reduced for those taking 5 or 6 effective drugs.
Definitions
...ons...
Summary of Good Practices
...ary of Good Practices...
Treatment
...atment...
...lection of an effective MDR-TB treatment regim...
...gest using at least five drugs in t...
...suggest an intensive-phase duration...
...suggest a total treatment duration of between 15 a...
...patients with pre-extensively drug-resista...
...e selection of oral drugs for MDR-TB trea...
...ecommend including a later-generation fluoroqui...
...mend including bedaquiline. (S, VL)620...
...t including linezolid. (C, VL)620...
...e suggest including clofazimine. (C, VL...
...e suggest including cycloserine. (C, VL...
...cluding ethambutol only when other more effective...
...including pyrazinamide in a regimen for treat...
...anel was unable to make a clinical r...
...elected oral drugs previously incl...
...recommend NOT including amoxicillin...
...NOT including the macrolides azithromycin and...
...NOT including ethionamide/prothiona...
...T including p-aminosalicylic acid in a regimen...
...ection of drugs administered through injection...
...uggest including amikacin or streptomycin whe...
...cluding a carbapenem (always to be use...
...OT including kanamycin or capreomycin. (C, V...
...r the use of the WHO-recommended standardize...
...rse regimen is standardized with the use of ka...
...or the role of surgery in the treatment of M...
...t elective partial lung resection (e.g., lo...
...dical therapy alone, rather than including...
...the treatment of isoniazid-resi...
...suggest adding a later-generation f...
...ients with isoniazid-resistant TB treated with...
...anagement of contacts to patients w...
...st offering treatment for latent TB infection (L...
Table 1. Summary of Recommendations on Drugs for...
...Clinical Strategy to Build an Indivi...
...es of Drugs for Treatment of Adult...
...t Antiretroviral and Non–rifamycin-ba...