Treatment of Drug-Resistant Tuberculosis
Key Points
Key Points
MDR-TB is defined specifically as resistance to at least isoniazid and rifampin, the two most important first-line drugs.
The guideline is intended for settings in which treatment is individualized and where mycobacterial cultures, molecular (genotypic) and culture-based (phenotypic) drug susceptibility tests (DSTs), and radiographic facilities are available.
Treatment success was most likely with regimens for MDR-TB containing 5 effective drugs in the intensive phase. Mortality was also significantly reduced for those taking 5 or 6 effective drugs.
Definitions
...s...
Summary of Good Practices
...Practices...
Treatment
...reatment
...ction of an effective MDR-TB treatment regimen...
...at least five drugs in the intensive phase...
...e suggest an intensive-phase duration of treatment...
...ggest a total treatment duration of betw...
...s with pre-extensively drug-resist...
...lection of oral drugs for MDR-TB treatment...
...d including a later-generation fluoroquinolo...
...ommend including bedaquiline. (S, V...
...est including linezolid. (C, VL)620
...including clofazimine. (C, VL)620...
...e suggest including cycloserine. (C, VL...
...t including ethambutol only when other mor...
...including pyrazinamide in a regimen fo...
...uideline panel was unable to make a clin...
...oral drugs previously included in re...
...ecommend NOT including amoxicillin-...
...e recommend NOT including the macrolides azithr...
...OT including ethionamide/prothionamide...
...gest NOT including p-aminosalicylic acid in a reg...
...selection of drugs administered through...
...e suggest including amikacin or streptomycin...
...ncluding a carbapenem (always to be used...
...suggest NOT including kanamycin or capreomycin. (...
...the WHO-recommended standardized shorte...
...e shorter-course regimen is standardized with...
...surgery in the treatment of MDR-TB:...
...suggest elective partial lung resectio...
...st medical therapy alone, rather than i...
...tment of isoniazid-resistant TB:...
We suggest adding a later-generation fluoro...
...ith isoniazid-resistant TB treated with a daily re...
...the management of contacts to patients with MDR...
...fering treatment for latent TB infection (...
...Summary of Recommendations on Drugs fo...
...al Strategy to Build an Individualized Treatment...
...2b. Doses of Drugs for Treatment of Adu...
...lect Antiretroviral and Non–rifamy...