Treatment of Drug-Resistant Tuberculosis
Key Points
Key Points
MDR-TB is defined specifically as resistance to at least isoniazid and rifampin, the two most important first-line drugs.
The guideline is intended for settings in which treatment is individualized and where mycobacterial cultures, molecular (genotypic) and culture-based (phenotypic) drug susceptibility tests (DSTs), and radiographic facilities are available.
Treatment success was most likely with regimens for MDR-TB containing 5 effective drugs in the intensive phase. Mortality was also significantly reduced for those taking 5 or 6 effective drugs.
Definitions
...ns...
Summary of Good Practices
...mmary of Good Practices...
Treatment
...atment...
...e selection of an effective MDR-TB tre...
...using at least five drugs in the i...
...an intensive-phase duration of treatment of...
...suggest a total treatment duration of be...
...n patients with pre-extensively dr...
...the selection of oral drugs for MD...
...cluding a later-generation fluoroquinolone (l...
...d including bedaquiline. (S, VL)620...
...e suggest including linezolid. (C...
We suggest including clofazimine. (C, VL)620
...gest including cycloserine. (C, VL)620...
...cluding ethambutol only when other more ef...
...suggest including pyrazinamide in a regimen...
The guideline panel was unable to make a clinic...
...l drugs previously included in regimen...
...ommend NOT including amoxicillin-clavul...
...T including the macrolides azithromyc...
...gest NOT including ethionamide/prothion...
...uggest NOT including p-aminosalicylic acid in a...
...the selection of drugs administered through inje...
...t including amikacin or streptomycin...
...including a carbapenem (always to be used with a...
...NOT including kanamycin or capreomyc...
...se of the WHO-recommended standardized shorter-...
...rter-course regimen is standardized with the u...
...surgery in the treatment of MDR-TB:...
...ctive partial lung resection (e.g., lobec...
...dical therapy alone, rather than including e...
...the treatment of isoniazid-resistant...
...t adding a later-generation fluoroquinolone...
...with isoniazid-resistant TB treated with...
...he management of contacts to patients with MDR-TB...
...gest offering treatment for latent T...
.... Summary of Recommendations on Drug...
...al Strategy to Build an Individualized...
...es of Drugs for Treatment of Adults and Chi...
.... Select Antiretroviral and Non–rifamycin-b...