Chemotherapy in Combination With Radiotherapy for Definitive-Intent Treatment of Stage II-IVA Nasopharyngeal Carcinoma
Key Points
Key Points
- Nasopharyngeal carcinoma (NPC) is uncommon in many jurisdictions but remains a significant public health problem in East and Southeast Asia, which accounted for more than 70% of the approximate 129,000 new diagnoses worldwide in 2018.
- NPC relies almost exclusively on (chemo-)radiotherapy to achieve disease control in most presentations, particularly in the definitive treatment of stage II to IVA disease.
Treatment
...Treatmen...
...Radiotherapy:...
....1For all nasopharyngeal carcinoma (NPC...
...1.2For all NPC patients, both sequential b...
...ndation 1.3For all NPC patients, a prescribed...
...mendation 1.4For all NPC patients, gross tumor...
...mendation 1.5For NPC patients who h...
...ommendation 1.6The delineation of elec...
...Chemotherapy Sequence...
...ndation 2.1For T2N0 (AJCC 8th) NPC patients...
...n 2.2For T1-2N1 (AJCC 8th) NPC patients,...
Recommendation 2.3For Stage III–IVA (...
....4For Stage III–IVA (except T3N0) (AJCC...
...ommendation 2.5For T3N0 (AJCC 8th) NPC patients, c...
...Concurrent Che...
...3.1For all NPC patients without cont...
...mmendation 3.2For all NPC patients without co...
...ation 3.3For NPC patients with a contraind...
...ndation 3.4For NPC patients with a contrain...
...Induction Chemot...
...mendation 4.1For all NPC patients receiving in...
....2For NPC patients receiving induction chemot...
...endation 4.3For NPC patients receiving...
...Adjuvant Chemother...
...ommendation 5.1For all NPC patients r...
...on 5.2For all NPC patients receiving adjuvant...
...mmendation 5.3For all NPC patients re...
...II to IVA Nasopharyngeal Carcinoma...