Multimodality Therapy for Locally-Advanced Cancer of the Esophagus or Gastroesophageal Junction

Induction chemotherapy before preoperative CRT with a positron emission tomography (PET)-based response assessment and adaptation of the regimen accordingly during CRT may be reasonable in patients with resectable esophageal adenocarcinoma (AC). (IIb, B-NR)

In patients with locally-advanced SCC of the esophagus, nCRT is reasonable to choose over neoadjuvant chemotherapy (nCT). (IIa, B-R)