Management of Clostridioides difficile Infection
Publication Date: May 31, 2021
Last Updated: March 14, 2022
Recommendations
Evaluation
1. When CDI is suspected, a disease-specific history should be performed emphasizing risk factors, symptoms, underlying comorbidities, and signs of severe or fulminant disease. (1C)
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2. Patients should be evaluated to determine the severity of CDI and for the presence of peritonitis or multisystem organ failure. (1C)
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3. The diagnosis of CDI should include laboratory stool testing, and 2-step testing should be utilized to increase accuracy. (1A)
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4. Routine endoscopic evaluation to diagnose or determine the extent of CDI is not recommended. (1C)
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5. Radiologic evaluation has limited utility in the setting of CDI. (2C)
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Title
Management of Clostridioides difficile Infection
Authoring Organization
American Society of Colon and Rectal Surgeons