Treatment of Central Disorders of Hypersomnolence

Publication Date: April 23, 2021
Last Updated: March 14, 2022

ADULT PATIENTS WITH NARCOLEPSY

1. We recommend that clinicians use modafinil for the treatment of narcolepsy in adults. (Strong)
345720

2. We recommend that clinicians use pitolisant for the treatment of narcolepsy in adults. (Strong)
345720

3. We recommend that clinicians use sodium oxybate for the treatment of narcolepsy in adults. (Strong)
345720

4. We recommend that clinicians use solriamfetol for the treatment of narcolepsy in adults. (Strong)
345720

5. We suggest that clinicians use armodafinil for the treatment of narcolepsy in adults. (Conditional)
345720

6. We suggest that clinicians use dextroamphetamine for the treatment of narcolepsy in adults. (Conditional)
345720

7. We suggest that clinicians use methylphenidate for the treatment of narcolepsy in adults. (Conditional)
345720


ADULT PATIENTS WITH IDIOPATHIC HYPERSOMNIA

8. We recommend that clinicians use modafinil for the treatment of idiopathic hypersomnia in adults. (Strong)
345720

9. We suggest that clinicians use clarithromycin for the treatment of idiopathic hypersomnia in adults. (Conditional)
345720

10. We suggest that clinicians use methylphenidate for the treatment of idiopathic hypersomnia in adults. (Conditional)
345720

11. We suggest that clinicians use pitolisant for the treatment of idiopathic hypersomnia in adults. (Conditional)
345720

12. We suggest that clinicians use sodium oxybate for the treatment of idiopathic hypersomnia in adults. (Conditional)
345720

ADULT PATIENTS WITH KLEINE-LEVIN SYNDROME

13. We suggest that clinicians use lithium for the treatment of Kleine-Levin syndrome in adults. (Conditional)
345720

ADULT PATIENTS WITH HYPERSOMNIA DUE TO MEDICAL CONDITIONS

HYPERSOMNIA SECONDARY TO ALPHA-SYNUCLEINOPATHIES

14. We suggest that clinicians use armodafinil for the treatment of hypersomnia secondary to dementia with Lewy bodies in adults. (Conditional)
345720
15. We suggest that clinicians use modafinil for the treatment of hypersomnia secondary to Parkinson’s disease in adults. (Conditional)
345720
16. We suggest that clinicians use sodium oxybate for the treatment of hypersomnia secondary to Parkinson’s disease in adults. (Conditional)
345720

POSTTRAUMATIC HYPERSOMNIA

17. We suggest that clinicians use armodafinil for the treatment of hypersomnia secondary to traumatic brain injury in adults. (Conditional)
345720
18. We suggest that clinicians use modafinil for the treatment of hypersomnia secondary to traumatic brain injury in adults. (Conditional)
345720

ADULT PATIENTS WITH GENETIC DISORDERS ASSOCIATED WITH PRIMARY CENTRAL NERVOUS SYSTEM SOMNOLENCE

19. We suggest that clinicians use modafinil for the treatment of hypersomnia secondary to myotonic dystrophy in adults. (Conditional)
345720

ADULT PATIENTS WITH HYPERSOMNIA SECONDARY TO BRAIN TUMORS, INFECTIONS, OR OTHER CENTRAL NERVOUS SYSTEM LESIONS

20. We suggest that clinicians use modafinil for the treatment of hypersomnia secondary to multiple sclerosis in adults. (Conditional)
345720

PEDIATRIC PATIENTS WITH NARCOLEPSY

21. We suggest that clinicians use modafinil for the treatment of narcolepsy in pediatric patients. (Conditional)
345720

22. We suggest that clinicians use sodium oxybate for the treatment of narcolepsy in pediatric patients. (Conditional)
345720

Recommendation Grading

Disclaimer

Overview

Title

Treatment of Central Disorders of Hypersomnolence

Authoring Organization

Publication Month/Year

April 23, 2021

Last Updated Month/Year

July 12, 2023

Supplemental Implementation Tools

Document Type

Guideline

External Publication Status

Published

Country of Publication

US

Inclusion Criteria

Male, Female, Adult, Older adult

Health Care Settings

Ambulatory, Hospital, Outpatient

Intended Users

Nurse, nurse practitioner, physician, physician assistant

Scope

Treatment

Diseases/Conditions (MeSH)

D020177 - Idiopathic Hypersomnia

Keywords

hypersomnolence, narcolepsy, kleine-Levin Syndrome, hypersomnia, posttraumaric hypersomnia, Idiopathic hypersomnia

Supplemental Methodology Resources

Systematic Review Document