Oocyte Cryopreservation for Donor Oocyte In Vitro Fertilization and Planned Oocyte Cryopreservation

There is insufficient evidence to counsel women about the likelihood of live birth after planned OC.

It is recommended that OC be offered as an option for to women in situations where there is an unanticipated lack of sperm the day of retrieval, or a desire to limit the number of fertilized embryos.

It is recommended to counsel women that live birth rates per embryo transfer are improved when OC is performed in younger women as compared to older women.

There are insufficient data to advise women on the optimal age to undergo planned OC.

There is insufficient evidence to recommend that demographic characteristics or comorbidities independent of age affect the outcome of planned OC.

There is insufficient evidence to recommend interventions to optimize outcomes after planned OC.

There is insufficient evidence to recommend ovarian reserve testing to predict live birth rates after planned OC for any indication, independent of age.

There is insufficient evidence to counsel women of various ages on the absolute number of oocytes necessary to achieve live birth after planned OC.

Infertile women should be counseled that, based on a small number of births, neonatal outcomes appear similar after using their own previously cryopreserved oocytes compared with outcomes after the use of fresh oocytes.

There is insufficient evidence to counsel patients regarding the likelihood of the long-term use of oocytes cryopreserved for planned OC.

It is recommended to tell recipients that previously cryopreserved donor oocytes are a reasonable option compared with fresh donor oocytes, given that there is good evidence that there are no significant differences in per transfer pregnancy rates compared with those with fresh donor oocytes.

Recipients can be counseled that as the number of donor oocytes warmed increases, there is an associated increase in cumulative live birth rate.

Recipients can be counseled that live birth rates may be greater from vitrified oocytes that derive from donors who had prior successful outcome after a fresh cycle of oocyte donation.

Recipients can be counseled that the length of time that oocytes have been stored is not associated with differences in oocyte survival or pregnancy rates.

There is insufficient evidence to recommend a particular stimulation protocol for oocyte donors or certain donor characteristics in terms of embryo quality or success rates. Recipients can be counseled that, based on limited evidence, neonatal outcomes appear similar between vitrified and fresh donor oocytes.

There is insufficient evidence to predict live birth rates after planned OC.

On the basis of limited data, ongoing and live birth rates appear to be higher for women who undergo planned OC at a younger vs. older ages.

Ovarian reserve tests can be used to estimate the anticipated oocyte yield.

There are no significant differences in per transfer pregnancy rates with cryopreserved vs. fresh donor oocytes.

Neonatal outcomes appear similar with cryopreserved oocytes.