Evaluation and Management of Well-Appearing Febrile Infants 8 to 60 Days Old

 KAS 1: Should obtain urine specimen by catheterization or suprapubic aspiration (SPA) of bladder for urinalysis and, if urinalysis result is positive, for culture.

 KAS 2: Should obtain a blood culture.

 KAS 3: May assess inflammatory markers (IMs).

 KAS 4: Should obtain CSF for analysis (WBC, protein, glucose, Gram stain) and culture for bacteria. See notes for viral testing.

 KAS 5: Should initiate parenteral antimicrobial therapy.

 KAS 6: Should actively monitor infants while awaiting results of bacterial cultures in a hospital setting with nurses and staff experienced in the care of neonates/young infants.

 KAS 7a: Should discontinue parenteral antimicrobial agents and discharge hospitalized patients when all of the following criteria are met: (1) culture results are negative for 24–36 h or only positive for contaminants; (2) the infant continues to appear clinically well or is improving (eg, fever, feeding); (3) tare no other reasons for hospitalization.

 KAS 7b: Should treat infants’ positive bacterial pathogens in urine, blood, or CSF with targeted antimicrobial therapy for the duration of time consistent with the nature of the disease, responsible organism, and response of the infant to treatment.