ASTRO Radiation Therapy for Treatment of Soft Tissue Sarcoma in Adults Guideline Summary - Guideline Central
Roles and indications for RT in the treatment of extremity and superficial truncal adult STS
Sequence of RT and surgery for extremity and superficial truncal adult STS
Dose-fractionation regimens and target volumes for EBRT in extremity and superficial truncal adult STS
RT simulation, planning, and delivery techniques for EBRT of extremity and superficial truncal adult STS
Role for RT, dose-fractionation regimens, and treatment planning for RPS
Document Overview

Radiation Therapy for Treatment of Soft Tissue Sarcoma in Adults

American Society for Radiation Oncology


Publication Date: Jul 24, 2021

Page Last Updated: Mar 23, 2026

American Society for Radiation Oncology Grading System

GradeStrength of Recommendation
StrongFor the PatientFor the Clinician
Most individuals in this situation would want the recommended course of action and only a small proportion would not.
  • Most individuals in this situation would want the recommended course of action and only a small proportion would not.
  • The majority of individuals in this situation would want the suggested course of action, but many would not.
Conditional (weak)The majority of individuals in this situation would want the suggested course of action, but many would not.
  • Different choices will be appropriate for different patients.
  • Decision aids may well be useful in helping individuals making decisions consistent with their values and preferences.
  • Clinicians should expect to spend more time with patients when working toward a decision.
 
GradeQuality of Evidence
HighWe are very confident that the true effect lies close to that of the estimate of the effect.
ModerateWe are moderately confident in the effect estimate. The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
LowOur confidence in the effect estimate is limited. The true effect may be substantially different from the estimate of the effect.
Expert OpinionA lower quality of evidence, including expert opinion, does not imply that the recommendation is conditional. Many important clinical questions addressed in guidelines do not lend themselves to clinical trials but there still may be consensus that the benefits of a treatment or diagnostic test clearly outweigh its risks and burden.

Document Overview

Document Title
Radiation Therapy for Treatment of Soft Tissue Sarcoma in Adults
Authoring Society

American Society for Radiation Oncology

Document Publication Date
Jul 24, 2021
Page Last Reviewed/Updated
Mar 23, 2026
Document Type
Guideline
Country of Publication
United States
Full Text Freely Available
Yes
Full Text Guideline
www.practicalradonc.org/article/S1879-8500(21)00118-1/fulltext#seccesectitle0001
Source Citation

Salerno KE, Alektiar KM, Baldini EH, Bedi M, Bishop AJ, Bradfield L, Chung P, DeLaney TF, Folpe A, Kane JM, Li XA, Petersen I, Powell J, Stolten M, Thorpe S, Trent JC, Voermans M, Guadagnolo BA. Radiation Therapy for Treatment of Soft Tissue Sarcoma in Adults: Executive Summary of an ASTRO Clinical Practice Guideline. Pract Radiat Oncol. 2021 Sep-Oct;11(5):339-351. doi: 10.1016/j.prro.2021.04.005. Epub 2021 Jul 26. PMID: 34326023.

Supplemental Implementation Resources

Document Scope, Criteria, and Use Cases

Scope
Management, Treatment
Diseases/Conditions (MeSH)

D012509 - Sarcoma

D064746 - Therapy, Soft Tissue

Keywords
Clinical Practice Guideline, radiation therapy, soft tissue sarcoma
Inclusion Criteria
Male, Female, Adult
Health Care Settings
Ambulatory, Hospital, Outpatient
Intended Users
Nurse, Nurse Practitioner, Physician, Physician Assistant

Recommendation Development Processes & Methodology

Supplemental Methodology Resource
Data Supplement
Number of Source Documents
162
Includes peer/external review process?
Yes
Includes public comment process?
Yes
Methodologist involvement?
Yes
Patient involvement?
No
Includes multi-disciplinary group?
Yes
Includes systematic review?
Yes
Grades quality of strength of evidence?
Yes
Grades quality of strength of recommendation?
Yes
Discloses funding source?
Yes
Discloses conflicts of interest?
Yes
Includes benefits/harms analysis with recommendations?
No
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