Management of Pregnancy and Delivery in Congenital Fibrinogen Disorders

Authoring Organization

Publication Month/Year

January 22, 2024

Last Updated Month/Year

February 19, 2024

Supplemental Implementation Tools

Document Type


Country of Publication


Document Objectives

Congenital fibrinogen disorders (CFDs) are a heterogeneous group of rare congenital quantitative and / or qualitative fibrinogen deficiency. The spectrum of molecular anomalies is broad, leading to several subtypes of fibrinogen disorders (i.e., afibrinogenemia, hypofibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia). Pregnancy in women with CFDs is a high-risk clinical situation, with an increased tendency to miscarriages, bleeding, and thrombosis. Even though it is well established that management of such pregnancies requires a multidisciplinary approach involving specialists (hematologists and maternal / fetal medicine experts with expertise in the management of inherited bleeding disorders), specific guidelines are lacking. In this ISTH SSC communication, we aim to propose an expert consensus opinion with literature evidence where available on the strategy for management of pregnancy, delivery, and puerperium in CFDs.

Inclusion Criteria

Female, Adult

Health Care Settings

Ambulatory, Hospital, Outpatient

Intended Users

Nurse, nurse midwife, nurse practitioner, physician, physician assistant


Assessment and screening, Management

Diseases/Conditions (MeSH)

D000347 - Afibrinogenemia


pregnancy, afibrinogenemia, Fibrinogen Deficiency, fibrinogen, Hypofibrinogenemia

Source Citation

Casini A, Kadir RA, Abdelwahab M, Manco-Johnson MJ, Raut S, Ross C, de Moerloose P, Santoro C, Acharya S, Management of pregnancy and delivery in congenital fibrinogen disorders: Communication from the ISTH SSC Subcommittee on Factor XIII and Fibrinogen, Journal of Thrombosis and Haemostasis (2024), doi: https://doi.org/10.1016/j.jtha.2024.01.008