Newer Pharmacologic Treatments in Adults With Type 2 Diabetes

Publication Date: April 19, 2024
Last Updated: April 19, 2024

Summary of Recommendations

ACP recommends adding a sodium–glucose cotransporter-2 (SGLT-2) inhibitor or glucagon-like peptide-1 (GLP-1) agonist to metformin and lifestyle modifications in adults with type 2 diabetes and inadequate glycemic control. (S, H )
  • Use an SGLT-2 inhibitor to reduce the risk for all-cause mortality, major adverse cardiovascular events, progression of chronic kidney disease, and hospitalization due to congestive heart failure.
  • Use a GLP-1 agonist to reduce the risk for all-cause mortality, major adverse cardiovascular events, and stroke.
620
ACP recommends against adding a dipeptidyl peptidase-4 (DPP-4) inhibitor to metformin and lifestyle modifications in adults with type 2 diabetes and inadequate glycemic control to reduce morbidity and all-cause mortality. (S, H )
620

Recommendation Grading

Disclaimer

The information in this patient summary should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.

Overview

Title

Newer Pharmacologic Treatments in Adults With Type 2 Diabetes

Authoring Organization

Publication Month/Year

April 19, 2024

Last Updated Month/Year

May 1, 2024

Supplemental Implementation Tools

Document Type

Guideline

Country of Publication

US

Document Objectives

The American College of Physicians (ACP) developed this clinical guideline to update recommendations on newer pharmacologic treatments of type 2 diabetes. This clinical guideline is based on the best available evidence for effectiveness, comparative benefits and harms, consideration of patients’ values and preferences, and costs.

Target Patient Population

Adults with type 2 diabetes

Target Provider Population

Internists, family practitioners, and other clinicians caring for patients with T2DM

Inclusion Criteria

Male, Female, Adult, Older adult

Health Care Settings

Ambulatory

Intended Users

Nurse, nurse practitioner, physician, physician assistant

Scope

Treatment, Management

Diseases/Conditions (MeSH)

D003920 - Diabetes Mellitus, D003924 - Diabetes Mellitus, Type 2

Keywords

diabetes, diabetes mellitus, type 2 diabetes mellitus, Type 2 Diabetes , GLP-1, SGLT-2

Source Citation

Amir Qaseem, Adam J. Obley, Tatyana Shamliyan, et al; Clinical Guidelines Committee of the American College of Physicians. Newer Pharmacologic Treatments in Adults With Type 2 Diabetes: A Clinical Guideline From the American College of Physicians. Ann Intern Med. [Epub 19 April 2024]. doi:10.7326/M23-2788