Germline Genetic Testing for Cancer

Publication Date: May 17, 2024

 Key Points

 Key Points

  • Family history plays an important role in informing appropriate gene selection for germline testing.
  • The number of genes available on germline panels varies widely, ranging from a few to more than a hundred.
  • It is important to recognize that tumor testing is not a substitute for germline testing. Therefore, any individual meeting the criteria for germline genetic testing should still undergo clinical genetic testing optimized for detection of germline variants, regardless of the tumor profiling results.

Diagnosis

...gnosis...

...ly History Collection

...Recommendation 1.1All patients should have a famil...

...ecommendation 1.2 Patients shoul...


...rmline Multi-gene Panel Testing

...ommendation 2.1When germline genetic testing...

...ation 2.2When considering what to order for...


...line Multi-gene Panel Test...

...n 3If germline multi-gene panel testing is offere...


...Included in Multi-gene Panels...

...on 4.1Patients who meet criteria for...

....2Regardless of germline genetic testing crit...


...Recommended for Testing and Inclusion in Mu...


...2. Genes for Which Pathogenic Variants...


...rs Relevant to Each Gene if a Conservati...


...Figure 1. Selection of Genes for Multi-gene...


...ne Testing in Response to Tumor Testin...


...O believes that cancer clinical tr...