Germline Genetic Testing for Cancer

Publication Date: May 17, 2024

 Key Points

 Key Points

  • Family history plays an important role in informing appropriate gene selection for germline testing.
  • The number of genes available on germline panels varies widely, ranging from a few to more than a hundred.
  • It is important to recognize that tumor testing is not a substitute for germline testing. Therefore, any individual meeting the criteria for germline genetic testing should still undergo clinical genetic testing optimized for detection of germline variants, regardless of the tumor profiling results.

Diagnosis

...agnosis

Family History Co...

... Recommendation 1.1All patients sh...

...ion 1.2 Patients should be asked to provi...


Germline Multi-gene Pa...

...ndation 2.1When germline genetic tes...

...ation 2.2When considering what to order...


...e Multi-gene Panel Testing...

...ndation 3If germline multi-gene panel testing i...


...Included in Multi-gene Panels...

...ion 4.1Patients who meet criteria fo...

...ion 4.2Regardless of germline genetic testing crit...


...Recommended for Testing and Inclusion in Multi-...


...Genes for Which Pathogenic Variants Id...


...rs Relevant to Each Gene if a Conserva...


...ure 1. Selection of Genes for Multi-gene Pane...


...ermline Testing in Response to Tumor Testing...


...ASCO believes that cancer clinic...