Transbronchial Cryobiopsy for the Diagnosis of Interstitial Lung Diseases

Publication Date: April 1, 2020
Last Updated: March 14, 2022

SUMMARY OF RECOMMENDATIONS

In patients with suspected interstitial lung disease (ILD), we suggest that transbronchial cryobiopsy (TBC) can be used to provide histopathologic findings for multidisciplinary discussion (MDD) diagnosis. (W-VL)
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In patients with suspected ILD undergoing transbronchial cryobiopsy, we suggest biopsy of at least two different sites (either different segments in the same lobe or different lobes). (W-L)
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In patients with suspected ILD undergoing transbronchial cryobiopsy, we suggest biopsy with the tip of the cryoprobe located 1 cm from the pleura. (U-CBS)
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In patients with suspected ILD undergoing transbronchial cryobiopsy, we suggest the use of fluoroscopy. (U-CBS)
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In patients with suspected ILD undergoing transbronchial cryobiopsy, we suggest that transbronchial cryobiopsy be performed with a bronchial blocker either through an endotracheal tube or rigid bronchoscope. (U-CBS)
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In patients with suspected ILD undergoing transbronchial cryobiopsy, we suggest the use of a small cryoprobe (1.9 mm) rather than a larger cryoprobe (2.4mm). (U-CBS)
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Recommendation Grading

Overview

Title

Transbronchial Cryobiopsy for the Diagnosis of Interstitial Lung Diseases

Authoring Organization

Publication Month/Year

April 1, 2020

Last Updated Month/Year

July 6, 2023

Supplemental Implementation Tools

Document Type

Guideline

External Publication Status

Published

Country of Publication

US

Inclusion Criteria

Female, Male, Adult, Older adult

Health Care Settings

Hospital, Laboratory services, Outpatient

Intended Users

Laboratory technician, nurse, nurse practitioner, physician, physician assistant

Scope

Management, Treatment

Diseases/Conditions (MeSH)

D017563 - Lung Diseases, Interstitial

Keywords

interstitial lung disease, transbronchial cryobiopsy, surgical lung biopsy

Source Citation

Maldonado F, Danoff SK, Wells AU, Colby TV, Ryu JH, Liberman M, Wahidi MM, Frazer L, Hetzel J, Rickman OB, Herth FJF, Poletti V, Yarmus LB. Transbronchial Cryobiopsy for the Diagnosis of Interstitial Lung Diseases: CHEST Guideline and Expert Panel Report. Chest. 2020 Apr;157(4):1030-1042. doi: 10.1016/j.chest.2019.10.048. Epub 2019 Nov 27. PMID: 31783014.