Management of Cancer Cachexia

Authoring Organization

Publication Month/Year

July 12, 2023

Document Type


External Publication Status


Country of Publication


Document Objectives

The purpose of this guideline is to provide evidence-based guidance on the optimal approach for the treatment of cachexia in patients with advanced cancer. Cachexia is a multifactorial syndrome characterized by loss of appetite, weight, and skeletal muscle, leading to fatigue, functional impairment, increased treatment-related toxicity, poor quality of life, and reduced survival.

Target Patient Population

Adult patients with advanced cancer and loss of appetite, body weight, and/or lean body mass (ie, skeletal muscle).

Target Provider Population

Clinicians who provide care to adult patients with cancer, as well as patients and caregivers.

Inclusion Criteria

Female, Male, Adult, Older adult

Health Care Settings

Ambulatory, Home health, Hospital, Long term care

Intended Users

Social worker, physician, health systems pharmacist, dietician nutritionist, nurse, nurse practitioner, physician assistant


Management, Treatment

Diseases/Conditions (MeSH)

D002100 - Cachexia


cancer, Cancer Cachexia, nutritional interventions, pharmacological interventions, precachexia, refractory cachexia, cachexia

Source Citation

Eric J. Roeland, MD; Kari Bohlke, ScD; Vickie E. Baracos, PhD; Management of Cancer Cachexia: ASCO Guideline update. J Clin Oncol. 2023 July 12. doi: 10.1200/JCO.23.01280

Eric J. Roeland, MD; Kari Bohlke, ScD; Vickie E. Baracos, PhD; Eduardo Bruera, MD; Egidio del Fabbro, MD; Suzanne Dixon, MPH, MS, RD; Marie Fallon, MD; Jørn Herrstedt, MD, DMSci; Harold Lau, MD; Mary Platek, PhD, MS, RD; Hope S. Rugo, MD; Hester H. Schnipper, LICSW; Thomas J Smith, MD; Winston Tan, MD; Charles L. Loprinzi, MD. Management of Cancer Cachexia: ASCO Guideline. J Clin Oncol. 2020 May 20 doi: 10.1200/JCO.20.00611

Supplemental Methodology Resources

Data Supplement