Obesity

Publication Date: January 2, 2015

Key Points

Key Points

  • The Task Force agrees with the opinion of prominent medical societies that current scientific evidence supports the view that obesity is a disease.
  • Weight loss produces many benefits including risk factor improvement, prevention of disease, and improvements in feeling and function. Greater weight loss produces greater benefits, but modest (5%–10%) weight loss, such as that produced by lifestyle modifications and medications, has been shown to produce significant improvements in many conditions.
  • Medications used for the management of conditions other than obesity can contribute to or exacerbate weight gain in susceptible individuals. Many of these conditions are also associated with obesity.
  • Health care providers can help patients prevent or attenuate weight gain by appropriately prescribing medications that would promote weight loss or minimize weight gain when treating these conditions.
  • Health care providers can help selected patients successfully lose weight and maintain lost weight by appropriately prescribing weight loss medications or in some cases surgical intervention as an adjunct to lifestyle change.

Diagnosis

Diagnosi...

...of ObesityHaving trouble viewing table?...


Table 2. Comorbid Conditions in Obesity and E...


Treatment

...atment...

...rine Society (ES) recommends that...


...ote long-term weight maintenance,...


...nts with uncontrolled HTN or history of...


...suggests assessment of efficacy and safety at...


...a patient’s response to a weight loss med...


...cation for chronic obesity management i...


...s with T2DM who are overweight or obese, ES sugges...


...n patients with CVD who seek pharmacol...


...se Weight Gain and Some Alternatives

ES recommends weight-losing and weight-neutral med...

...ts with T2DM requiring insulin therapy, ES sugg...

...S recommends ACE inhibitors, angiotensin re...

...tidepressant therapy is indicated, ES recommends...

...sing weight-neutral antipsychotic alternativ...

...considering weight gain potential...

...with a BMI >27 kg/m2 with comorbiditie...

...ggests monitoring the weight and wa...

...S suggests the use of NSAIDs and disease-modify...

...ests the use of antihistamines with less central...


...of Drugs Approved for Other Indications for...

...suggests against the off-label use of medicati...


...le 3. Drugs Associated with Weight Gain and Sugges...


...Advantages and Disadvantages Associated...


...able 5. Pharmacotherapy for Obesity in the Unit...