
Evaluation and Treatment of Hypertriglyceridemia
Key Points
Key Points
Diagnosis and Definitions
Causes of elevated triglycerides—primary and secondary
Table 1. Causes of Hypertriglyceridemia
Primary hypertriglyceridemia | |
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Primary genetic susceptibility | |
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Secondary hypertriglyceridemia | |
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Table 2. Criteria Proposed for Clinical Diagnosis of Elevated Triglyceride Levels Under Fasting Conditions
NCEP ATP III (3) | The Endocrine Society 2010a | ||||
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Normal | <150 mg/dL | <1.7 mmol/liter | Normal | <150 mg/dL | <1.7 mmol/liter |
Borderline-high triglycerides | 150-199 mg/dL | 1.7-2.3 mmol/liter | Mild HTG | 150-199 mg/dL | 1.7-2.3 mmol/liter |
High triglycerides | 200-499 mg/dL | 2.3-5.6 mmol/liter | Moderate HTG | 200-999 mg/dL | 2.3-11.2 mmol/liter |
Very high triglycerides | ≥500 mg/dL | ≥5.6 mmol/liter | Severe HTG | 1000-1999 mg/dL | 11.2-22.4 mmol/liter |
Very severe HTG | ≥2000 mg/dL | ≥22.4 mmol/liter |
Treatment
...Tre...
...Managemen...
...initial treatment of mild-to-moderate hypertriglyc...
...very severe hypertriglyceridemia (>1000 mg/dL...
...atment goal for patients with moderate hypertrigl...
...as a first-line agent for reduction of...
...nsider three drug classes (fibrate...
...NOT use statins as monotherapy for sev...
...Fibrates...
...Niacin Clinical tr...
...n-3 Fatty acids...
...gure 1. Management of Hypertriglyceridemia...