Dopaminergic Therapy for Motor Symptoms in Early Parkinson Disease

Authoring Organization

Publication Month/Year

November 16, 2021

Last Updated Month/Year

July 24, 2023

Document Type


External Publication Status


Country of Publication


Document Objectives

To review the current evidence on the options available for initiating dopaminergic treatment of motor symptoms in early-stage Parkinson disease and provide recommendations to clinicians.

Inclusion Criteria

Male, Female, Adult, Older adult

Health Care Settings

Ambulatory, Long term care

Intended Users

Nurse, nurse practitioner, physician, physician assistant


Treatment, Management

Diseases/Conditions (MeSH)

D000068079 - Motor Disorders, D010300 - Parkinson Disease, D009043 - Motor Activity, D059290 - Dopaminergic Neurons


parkinson, Parkinson's disease, Parkinson’s disease, motor symptoms

Source Citation

Pringsheim T, Day GS, Smith DB, Rae-Grant A, Licking N, Armstrong MJ, de Bie RMA, Roze E, Miyasaki JM, Hauser RA, Espay AJ, Martello JP, Gurwell JA, Billinghurst L, Sullivan K, Fitts MS, Cothros N, Hall DA, Rafferty M, Hagerbrant L, Hastings T, O'Brien MD, Silsbee H, Gronseth G, Lang AE; Guideline Subcommittee of the AAN. Dopaminergic Therapy for Motor Symptoms in Early Parkinson Disease Practice Guideline Summary: A Report of the AAN Guideline Subcommittee. Neurology. 2021 Nov 16;97(20):942-957. doi: 10.1212/WNL.0000000000012868. PMID: 34782410.

Supplemental Methodology Resources

Evidence Tables


Number of Source Documents
Literature Search Start Date
March 1, 2018
Literature Search End Date
June 1, 2020