Polyarteritis Nodosa

Publication Date: July 8, 2021

Key Points

Key Points

  • Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis that affects primarily medium-sized vessels.
  • The most common clinical manifestations are:
    • systemic: fever, weight loss
    • neurologic: mononeuritis multiplex, peripheral neuropathy
    • cutaneous: nodules, livedo reticularis
    • renal: hypertension
    • gastrointestinal: abdominal pain
  • Diagnosis is generally confirmed by tissue biopsy of an affected organ, or angiography if tissue biopsy cannot be obtained.

Definitions / Treatments

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Recommendations

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