Acute Hematogenous Osteomyelitis
Key Points
Key Points
- Acute hematogenous osteomyelitis (AHO) occurs when bacteria enter and proliferate within the cellular and extracellular matrix of bone, generally accompanied by a host inflammatory response.
- The incidence of AHO in children ranges from 1.2 to 13 cases per 100,000 children per year
- Most of the cases involve a single bone, but about 5% involve multiple bones.
- The presentation of AHO varies from well-localized infection over a single metaphysis with a minimal associated systemic inflammatory response to multifocal infection with septic shock.
- Fever and pain are the most common manifestations of bone infection.
Surveillance and Remediation
...llance and Remediation Acute osteom...
Diagnosis
...iagnosis
...atory Tests...
...ildren with suspected AHO, we recomme...
...dren with suspected AHO, we suggest...
...dren with suspected AHO, we suggest agai...
...ntial Diagnosis Infection of adjacen...
...edures In children with suspecte...
...aging
...ith suspected AHO, we recommend obtaining plai...
...n with suspected AHO requiring further ima...
Treatment
...atment...
...Antimicrobial Therapy...
...n with presumed AHO who are ill-appearing or have...
...ren with presumed AHO who are not...
...children with suspected AHO, we recomme...
...nitive Parenteral and Oral Thera...
...confirmed AHO, selection of a definitiv...
...dren with suspected AHO without an ident...
...en with AHO requiring a surgical procedure, we...
...asive Therapeutic Procedures
...with AHO who present with sepsis or h...
...with AHO who is clinically stable but i...
...the ResponseIn children with suspecte...
...rge Planning...
...hildren with suspected or documented AHO who resp...
...n with suspected or documented AHO wh...
...f AntibioticsIn children with AHO presumed or...
...d-of-Therapy Im...
...e recommend against obtaining end-of-therapy...
...against routine end-of-therapy plain ra...
...ren with complicated AHO or with involveme...
...esponse or Relapse...
...dren either experiencing primary treatmen...
...nicians should reassess the need for surgical in...
...ng-Term Follow-upIn children with AHO who a...
...1. Antibiotic Choice and Duration of Therapy f...
.... Antibiotic Dosages for Pediatric...