Acute Hematogenous Osteomyelitis
Key Points
Key Points
- Acute hematogenous osteomyelitis (AHO) occurs when bacteria enter and proliferate within the cellular and extracellular matrix of bone, generally accompanied by a host inflammatory response.
- The incidence of AHO in children ranges from 1.2 to 13 cases per 100,000 children per year
- Most of the cases involve a single bone, but about 5% involve multiple bones.
- The presentation of AHO varies from well-localized infection over a single metaphysis with a minimal associated systemic inflammatory response to multifocal infection with septic shock.
- Fever and pain are the most common manifestations of bone infection.
Surveillance and Remediation
...urveillance and Remediation Acute osteomyel...
Diagnosis
Di...
...Laboratory...
...th suspected AHO, we recommend performing bloo...
In children with suspected AHO, we su...
...suspected AHO, we suggest against using serum p...
...ifferential Diagnosis Infection of ad...
...sive Procedures In children with suspected...
...hildren with suspected AHO, we recommend...
...children with suspected AHO requiring fur...
Treatment
In children with presumed AHO who a...
...n with presumed AHO who are not clinically...
In children with suspected AHO, we r...
...Definitive Parenteral an...
...children with confirmed AHO, selectio...
In children with suspected AHO without...
...with AHO requiring a surgical procedure, we re...
Inv...
...h AHO who present with sepsis or have a r...
...th AHO who is clinically stable but is docu...
...nseIn children with suspected or co...
...Discharge Pl...
...r children with suspected or documented AHO w...
...r children with suspected or documented AHO who r...
...on of AntibioticsIn children with AHO pr...
...End-of-Therapy Imaging...
...commend against obtaining end-of-therapy MR...
...gest against routine end-of-therapy plain rad...
...with complicated AHO or with involvement of the p...
...Nonres...
...ldren either experiencing primary treatme...
...linicians should reassess the need for surgical...
...w-upIn children with AHO who are de...
...1. Antibiotic Choice and Duration of...
...Antibiotic Dosages for Pediatric Acute Hematogenou...