Hypothyroidism
Key Points
Key Points
There is no consistently strong evidence for the superiority of alternative preparations (e.g., levothyroxine–liothyronine combination therapy or thyroid extract therapy) over monotherapy with levothyroxine in improving health outcomes.
For patients who feel unwell while taking levothyroxine therapy there is currently insufficient evidence to support the routine use of combination therapy due to uncertainty about the long-term risk-benefit ratio.
Future research needs include the development of superior biomarkers of euthyroidism to supplement the use of serum TSH measurements and long term trials testing the health outcomes of combination therapy or thyroid extract therapy.
Treatment
...LEVOTH...
...is recommended as the preparation...
Levothyroxine placement therapy has t...
...lthough it may be helpful to follow chan...
...markers of thyroid hormone action are not recommen...
...opulations ( L , W )624...
...ents, high-risk thyroid cancer patients, pregna...
...hildhood hypothyroidism ( M , S )Note: Switches...
...use of different levothyroxine products may somet...
...there are preliminary small studies suggesting...
...ecause co-administration of food and l...
...TA recommends that, where feasible...
...hom levothyroxine dose requirements are...
...on or discontinuation of estrogen and an...
...n deciding on a starting dose of levothyr...
...id hormone therapy should be initiated as an i...
...he deleterious health effects of iatrogenic...
...adverse effects of thyroid hormone deficiency...
...lergy or intolerance to levothryox...
...ATA recommends considering patients’ underlyin...
...treatment goals of hypothyroidism are the...
...atients, levothyroxine should generally be...
...ion of daily levothyroxine is not successful in m...
...nsufficient evidence of benefit to recommend...
...established instruments used to measure hypot...
...atients with hypothyroidism, but normal serum TS...
...Hypothyroid...
...women with overt hypothyroidism should rece...
In infants, levothyroxine replaceme...
...children with overt hypothyroidism shou...
Due to the low risks of levothyroxine replacem...
...Secondary Hypot...
...patients with secondary hypothyroidism, the primar...
...h it may be helpful to follow changes in...
...th secondary hypothyroidism in whom the onl...
...Levothyroxine i...
...he ATA strongly recommends against the use...
...ATA recommends against the routine use of le...
...ds against the treatment of obesity...
...ATA recommends against the treatment...
...rotoxicosis should be treated with...
...THERAPIES OT...
...ds that levothyroxine be considered as r...
...here is no consistently strong evidence of supe...
...ients with primary hypothyroidism who feel unw...
...ently, genetic testing is not recommended as a...
...t-term outcome data in hypothyroid patients sugg...
...e uncontrolled and nonrandomized d...
...ommends against the use of syntheti...
...TA recommends against the routine use of compounde...
...ommends against the use of dietary supplements,...
...Wilson’...
...are no credible scientific data to...
...HOSP...
...alized, non-critically ill patients w...
...tic goal of levothyroxine replacement in no...
...ed but not critically ill patients, oral...
...r hospitalized but not critically i...
...ecommends against the routine use of...
...Myxedema Co...
...itial thyroid hormone replacement for myxede...
...c glucocorticoid coverage should be em...
...the possibility that thyroxine con...
...travenous levothyroxine treatment i...
...TA recommends against the use of l...
...recommends against the use of liothyronin...
...USE OF THYR...
...ugh preclinical data suggest that the conce...
...peutic goals of the treatment of patients...
Although preliminary data from small case...
...ETHICS FRAMEWORK...
...linical ethical principles in levothyroxine...
...Thyroid Hormone PreparationsHaving trouble view...
...ations Potentially Affecting Levothyrox...
...Tabl...
Unanswered Questions (Areas Needing Further Research)
...Unanswere...