Diagnosis, Risk Stratification, And Management Of Pulmonary Hypertension Of Sickle Cell Disease.
Publication Date: March 5, 2014
Key Points
Key Points
Pulmonary hypertension (PH) and right heart failure are well-established risk factors for mortality in sickle cell disease (SCD).
Observational studies have consistently shown that increased tricuspid regurgitant jet velocity (TRV) measured by Doppler echocardiography, an increased serum N-terminal pro–brain natriuretic peptide (NT-pro-BNP) level, and pulmonary hypertension measured by right heart catheterization are all independent risk factors for mortality in adults.
To reduce the variability and to improve the quality of care that patients with SCD receive, the ATS developed clinical practice guidelines to advise hematologists, pulmonologists, cardiologists, pediatricians, and internists about how to identify and manage patients with SCD who are at increased risk for mortality.
Observational studies have consistently shown that increased tricuspid regurgitant jet velocity (TRV) measured by Doppler echocardiography, an increased serum N-terminal pro–brain natriuretic peptide (NT-pro-BNP) level, and pulmonary hypertension measured by right heart catheterization are all independent risk factors for mortality in adults.
To reduce the variability and to improve the quality of care that patients with SCD receive, the ATS developed clinical practice guidelines to advise hematologists, pulmonologists, cardiologists, pediatricians, and internists about how to identify and manage patients with SCD who are at increased risk for mortality.
Diagnosis
...Diagnosis...
Risk stratification guides clinical decision m...
...d risk for mortality is defined as...
...ble 1. Sample Questions for Evalua...
...posed Algorithm for Evaluation of Pulmonar...
...gure 2. Echocardiogram of a Patient with...
Treatment
...ents with SCD who have an increased...
...with SCD who have an increased risk for mortali...
...tients with SCD who have RHC-confirmed PH, ven...
...patients with SCD who have elevated TRV alone...
...r most patients with SCD who have...
For select patients with SCD who have RHC-...
...patients with SCD who have RHC-confirmed mar...
...MedicationsHaving trouble viewing table? Expan...