Systemic Therapy for Melanoma

Publication Date: August 14, 2023

Key Points

Key Points

  • The clinical burden associated with the treatment of melanoma has been increasing due to rising incidence globally.
  • Since 2011, 12 new drugs have been approved for unresectable melanoma and 4 additional drugs have been approved in the adjuvant setting.
  • Overall survival for melanoma is improving rapidly, with dramatic increases in long-term survival observed from administration of these new therapies.
  • This guideline includes recommendations on uveal melanoma based on new clinical trial data.

Treatment

...eatmen...

...ant Systemic Therapy

...taneous Melanoma Eligible for...

...ndation 1.1.Neoadjuvant pembrolizumab (max...

...ndation 1.2.Patients with clinical...


...juvant Systemic Therapy...

...ted (Stage II, III, IV) Cutaneous Melanoma...

Recommendation 2.1.1.Adjuvant pembroli...

Recommendation 2.1.2.Adjuvant therapy should not...

...ommendation 2.2.For patients with resected...

...2.3.For patients with resected stage IIIA‚Ä...

Recommendation 2.4.No recommendati...

Recommendation 2.5.1.Patients with resec...

...ommendation 2.5.2...

...alone ( IC , M, , W )3336...

...s ipilimumab followed by nivolumab ( IC ,...

...olizumab alone ( IC , L , , W )3336

...nib plus trametinib (in patients with BRAF...


...temic Therapy Optio...

...able/Metastatic Cutaneous Melanoma...

....1.For patients with BRAF wild-type, unr...

....2.1.For patients with BRAF mutant (V600) unre...

...ndation 3.2.2....

...ation therapy with nivolumab plus ipilimumab...

...herapy with nivolumab plus ipilimumab is...

...n 3.3.After progression on anti-PD-1-base...

...ndation 3.4.After progression on 1s...

...3.5.For patients with injectable (cut...

...-Cutaneous Melanoma (Stage II or Greater)...

...mmendation 4.1.1.HLA-A*02:01-positive...

...n 4.1.2.For all patients with uveal...

...4.2.In the absence of further data, the consensu...

Recommendation 4.3.No recommendation for...


...nable Dose and Schedule Details fo...


...2. Reasonable Dose and Schedule Details...


...stemic Therapy for Melanoma...


...e 1. Systemic Therapy for Melanoma (con...