Systemic Therapy for Melanoma

Publication Date: August 14, 2023

Key Points

Key Points

  • The clinical burden associated with the treatment of melanoma has been increasing due to rising incidence globally.
  • Since 2011, 12 new drugs have been approved for unresectable melanoma and 4 additional drugs have been approved in the adjuvant setting.
  • Overall survival for melanoma is improving rapidly, with dramatic increases in long-term survival observed from administration of these new therapies.
  • This guideline includes recommendations on uveal melanoma based on new clinical trial data.

Treatment

...reatmen...

...oadjuvant Systemic T...

...lanoma Eligible for Resection...

...tion 1.1.Neoadjuvant pembrolizumab (maximu...

...1.2.Patients with clinical and resectable sta...


...nt Systemic Therapy...

...d (Stage II, III, IV) Cutaneous Melanoma

...endation 2.1.1.Adjuvant pembrolizumab...

...ommendation 2.1.2.Adjuvant therapy shou...

...ecommendation 2.2.For patients with resecte...

...on 2.3.For patients with resected...

Recommendation 2.4.No recommendation can...

...mendation 2.5.1.Patients with resected stag...

...ndation 2.5.2....

...b alone (Evidence Quality - Medium) ( IC , , ,...

...us ipilimumab followed by nivolumab ( IC , L , ,...

...alone ( IC , L , , W )3336...

...d dabrafenib plus trametinib (in pati...


...ic Therapy Option...

Unresectable/Metastatic Cutaneo...

Recommendation 3.1.For patients with BRAF wild-t...

...n 3.2.1.For patients with BRAF mutant (...

...ommendation 3.2...

...mbination therapy with nivolumab plus ipilim...

...ation therapy with nivolumab plus ipilimumab...

...endation 3.3.After progression on anti-...

...ecommendation 3.4.After progression on 1s...

...ommendation 3.5.For patients with injectable...

...Melanoma (Stage II or Greater)...

....1.1.HLA-A*02:01-positive patients with metas...

...tion 4.1.2.For all patients with uveal mela...

...ation 4.2.In the absence of further data...

...ation 4.3.No recommendation for or against any s...


...1. Reasonable Dose and Schedule Deta...


...ble Dose and Schedule Details for Recommended Reg...


...1. Systemic Therapy for M...


...stemic Therapy for Melanoma (cont'd...