Systemic Therapy for Melanoma
Key Points
Key Points
- The clinical burden associated with the treatment of melanoma has been increasing due to rising incidence globally.
- Since 2011, 12 new drugs have been approved for unresectable melanoma and 4 additional drugs have been approved in the adjuvant setting.
- Overall survival for melanoma is improving rapidly, with dramatic increases in long-term survival observed from administration of these new therapies.
- This guideline includes recommendations on uveal melanoma based on new clinical trial data.
Treatment
...eatment
...nt Systemic Therapy
...lanoma Eligible for Resection...
...endation 1.1.Neoadjuvant pembrolizumab (maximu...
...mendation 1.2.Patients with clinical an...
...nt Systemic Therapy...
...ge II, III, IV) Cutaneous Melanoma...
...ecommendation 2.1.1.Adjuvant pembrolizu...
...ecommendation 2.1.2.Adjuvant therapy should not b...
...mendation 2.2.For patients with resecte...
...2.3.For patients with resected stage IIIAâ...
...2.4.No recommendation can be made for or ag...
...tion 2.5.1.Patients with resected stage IV...
...commendation 2...
...volumab alone (Evidence Quality - Medi...
...ipilimumab followed by nivolumab ( IC ,...
...mbrolizumab alone ( IC , L , , W )3...
...plus trametinib (in patients with BRAF V600E...
...Therapy Options
...ctable/Metastatic Cutaneous Melanoma...
Recommendation 3.1.For patients with BR...
...ecommendation 3.2.1.For patients with BRAF muta...
...endation 3.2.2....
...apy with nivolumab plus ipilimumab is preferred...
...on therapy with nivolumab plus ipilimumab is pref...
...3.3.After progression on anti-PD-1-based t...
Recommendation 3.4.After progression on 1...
...tion 3.5.For patients with injectable (cutane...
...s Melanoma (Stage II or Greater)...
...mendation 4.1.1.HLA-A*02:01-positive pa...
...commendation 4.1.2.For all patients wit...
...ation 4.2.In the absence of further data,...
....3.No recommendation for or against any specific...
...1. Reasonable Dose and Schedule Deta...
...onable Dose and Schedule Details for Recommended...
...e 1. Systemic Therapy for Mel...
...re 1. Systemic Therapy for Melanoma (cont'...