Systemic Therapy for Melanoma
Key Points
Key Points
- The clinical burden associated with the treatment of melanoma has been increasing due to rising incidence globally.
- Since 2011, 12 new drugs have been approved for unresectable melanoma and 4 additional drugs have been approved in the adjuvant setting.
- Overall survival for melanoma is improving rapidly, with dramatic increases in long-term survival observed from administration of these new therapies.
- This guideline includes recommendations on uveal melanoma based on new clinical trial data.
Treatment
...Treatment...
...Neoadjuvant System...
...Cutaneous...
...endation 1.1.Neoadjuvant pembrolizuma...
...on 1.2.Patients with clinical and resectable...
...Adjuvant Systemic Th...
Resecte...
...2.1.1.Adjuvant pembrolizumab or nivolumab shou...
...ation 2.1.2.Adjuvant therapy should not be...
...2.2.For patients with resected stage IIIA–D di...
...n 2.3.For patients with resected stage I...
....4.No recommendation can be made for o...
....5.1.Patients with resected stage IV melanoma shou...
...endation 2.5.2.
...alone (Evidence Quality - Medium) ( IC , , ,...
...volumab plus ipilimumab followed by nivo...
...izumab alone ( IC , L , , W )3336
...ib plus trametinib (in patients with BRAF V60...
...Systemic...
...Unresectable/Met...
...ommendation 3.1.For patients with BRAF wild-type...
...dation 3.2.1.For patients with BRAF mutant (V600)...
...endation 3.2.2...
...erapy with nivolumab plus ipilimumab is pref...
...ination therapy with nivolumab plus i...
...ation 3.3.After progression on anti-PD-1-based th...
...commendation 3.4.After progression on 1st line...
...dation 3.5.For patients with injectable...
...Non-...
...on 4.1.1.HLA-A*02:01-positive pati...
....1.2.For all patients with uveal mel...
...n 4.2.In the absence of further data, the conse...
...commendation 4.3.No recommendation for or against...
.... Reasonable Dose and Schedule Detai...
...asonable Dose and Schedule Details for Re...
...gure 1. Systemic Therapy for Melanom...
...gure 1. Systemic Therapy for Melanoma (cont...