Systemic Therapy for Melanoma
Key Points
Key Points
- The clinical burden associated with the treatment of melanoma has been increasing due to rising incidence globally.
- Since 2011, 12 new drugs have been approved for unresectable melanoma and 4 additional drugs have been approved in the adjuvant setting.
- Overall survival for melanoma is improving rapidly, with dramatic increases in long-term survival observed from administration of these new therapies.
- This guideline includes recommendations on uveal melanoma based on new clinical trial data.
Treatment
Treatmen...
...eoadjuvant Systemic Ther...
...Melanoma Eligible for Resection...
...ion 1.1.Neoadjuvant pembrolizumab (maximum of...
....2.Patients with clinical and resectable stage II...
...uvant Systemic Therapy...
...II, III, IV) Cutaneous Melanoma...
...ndation 2.1.1.Adjuvant pembrolizumab or niv...
....1.2.Adjuvant therapy should not be...
Recommendation 2.2.For patients wit...
...on 2.3.For patients with resected stage IIIAâ...
...n 2.4.No recommendation can be made for or agai...
...mmendation 2.5.1.Patients with resected st...
...ecommendation 2.5....
...ab alone ( IC , M, , W...
...olumab plus ipilimumab followed by nivolumab (...
...ab alone ( IC , L , , W )3336...
...nib plus trametinib (in patients w...
...ystemic Therapy Options...
...ectable/Metastatic Cutaneous Melano...
...n 3.1.For patients with BRAF wild-type, unresect...
...mmendation 3.2.1.For patients with...
...ommendation 3.2.2....
...bination therapy with nivolumab plus...
...therapy with nivolumab plus ipili...
...dation 3.3.After progression on anti-P...
...ommendation 3.4.After progression on 1st line...
...ommendation 3.5.For patients with injectab...
...Melanoma (Stage II or Greater)...
...n 4.1.1.HLA-A*02:01-positive patien...
...on 4.1.2.For all patients with uveal melanoma...
...ommendation 4.2.In the absence of furt...
...ation 4.3.No recommendation for or against any s...
...able Dose and Schedule Details for Recommende...
...easonable Dose and Schedule Details for Reco...
...Systemic Therapy for Melanoma...
...e 1. Systemic Therapy for Melanoma (cont'd) a...