Biomarkers for Adjuvant Endocrine and Chemotherapy in Early-Stage Breast Cancer
Key Points
Key Points
Diagnosis
...iagnos...
...osed ER-positive, HER2-negative Breast Canc...
...DX (21-gene recurrence score)...
...1.1If a patient has node-negative breast can...
...endation 1.2In the group of patients in...
...1.3In the group of patients in Recom...
...mmendation 1.4If a patient is postmenop...
...ation 1.5In the group of patients in Recom...
...mendation 1.6If a patient is premenopausal...
...ion 1.7If a patient has node-positive brea...
...nt (70-gene signature...
...dation 1.8If a patient is older than 50 and...
...ation 1.9If a patient is 50 years...
...tion 1.10If a patient has low clinical ris...
...on 1.11If a patient has node-positive br...
...ct (12-gene risk score...
...ndation 1.12If a patient is postmeno...
Recommendation 1.13If a patient is pre...
...1.14If a patient has breast cancer wi...
...osigna (PAM50...
...dation 1.15If a patient is postmenopausal...
...ecommendation 1.16If a patient is premenopaus...
...ecommendation 1.17If a patient is po...
...on 1.18If a patient has node-positi...
...mmostra...
...here is insufficient evidence to r...
...Cancer Index (BCI)...
...f a patient has ER-positive, HER2-ne...
...tient has ER-positive, HER2-negative, node-positi...
...i67
...endation 1.19If a patient is postmenop...
....20If a patient is postmenopausal and ha...
...ecommendation 1.21Despite the limitations associ...
...nohistochemistry 4 (IHC4)
...ecommendation 1.22If a patient has node-negative...
...PA and PAI...
...nt has ER-positive, HER2-negative (node-negat...
...tient has HER2-positive breast canc...
...ocrine Therapy For ER Receptor-positi...
...EndoPredict, Prosigna, Ki67, or IHC4...
...mmendation 1.23If a patient has node...
BCI
...1.24If a patient has node-negative or...
...n 1.25If a patient has node-positive breast ca...
...al Treatment Score post-5 Years (...
...mmendation 1.26If a patient is postme...
...R2-positive Breast Cancer or TNBC
...X, EndoPredict, MammaPrint, BCI, Prosigna, Ki67,...
...tion 1.27If a patient has HER2-positive bre...
...ging Biomarkers...
...r-Infiltrating Lymphocytes (T...
...1.28If a patient has node-negative or node-positi...
...1 Testing
...ecommendation 1.29If a patient has node-n...
...irculating Tumor Cells (C...
...on 1.30If a patient has node-negative or nod...
...ting Tumor DNA (ctDNA)
...ion 1.31If a patient has node-negative or node-...
...e 1. Breast Cancer Biomarkers to Guide...
...gure 1. Algorithm on Biomarkers to...
...assification of Patients According to Clinic...
...ASCO believes that cancer clinical...