Laryngeal Cancer
Key Points
Key Points
For patients with locally advanced (T3, selected T4 or low volume T4) disease, organ-preservation surgery, combined chemotherapy and radiation, or radiation alone, offers the potential for larynx preservation without compromising overall survival.
For selected patients with extensive T3 or large T4a lesions and/or poor pretreatment laryngeal function, better survival rates and quality of life may
be achieved with total laryngectomy.
Patients with clinically involved regional cervical nodes (N+) who have a complete clinical and radiologic imaging response after chemoradiation
do not require elective neck dissection.
All patients should undergo a pretreatment, baseline assessment of voice and swallowing function and receive counseling regarding potential impact of treatment options on voice, swallowing, and quality of life.
Evaluation
...Evaluation...
As part of a comprehensive pretreatment eval...
...reatment voice and swallowing assessments s...
...l, performance status, and quality of...
Treatment
Treatm...
...Limited Stage (T1,...
...with T1, T2 laryngeal cancer should be treate...
...ngeal cancer can be treated with radiation or...
...success of the larynx preservation...
...excision of the primary tumor with intent to...
...recurrence after radiation therapy may be amen...
...d chemotherapy and radiation may be u...
...aryngeal cancer constitutes a wide spec...
...Advanced Stage (T3, T4)...
...-preservation surgery, combined chemotherapy...
...tients with extensive T3 or large T4a lesions and...
...should have multidisciplinary evaluation regar...
...y of patients with T3, T4 primary-...
...oradiation therapy offers a significantly...
...insufficient evidence to indicate...
...ts who desire larynx-preservation therapy...
...Regional Cervical Nodes...
...ts with T1, T2 lesions of the glott...
...ith advanced lesions of the glottis and all...
...th clinically involved regional cervic...
...nts with equivocal fluorodeoxyglucose (18...
...linically involved cervical nodes w...
...Patient...
...n of therapy for an individual patien...
There are no validated markers that consis...
...tinued cigarette smoking is associated with a...