Laryngeal Cancer
Key Points
Key Points
For patients with locally advanced (T3, selected T4 or low volume T4) disease, organ-preservation surgery, combined chemotherapy and radiation, or radiation alone, offers the potential for larynx preservation without compromising overall survival.
For selected patients with extensive T3 or large T4a lesions and/or poor pretreatment laryngeal function, better survival rates and quality of life may
be achieved with total laryngectomy.
Patients with clinically involved regional cervical nodes (N+) who have a complete clinical and radiologic imaging response after chemoradiation
do not require elective neck dissection.
All patients should undergo a pretreatment, baseline assessment of voice and swallowing function and receive counseling regarding potential impact of treatment options on voice, swallowing, and quality of life.
Evaluation
...valuation
...a comprehensive pretreatment evaluation, all...
...nt voice and swallowing assessments should est...
...nstrumental, performance status, and quality of...
Treatment
...reatmen...
...ited Stage (T1, T2)...
...ith T1, T2 laryngeal cancer should be tr...
...laryngeal cancer can be treated with radiat...
...ess of the larynx preservation approach m...
...sion of the primary tumor with intent to pre...
...l tumor recurrence after radiation therapy may be...
Combined chemotherapy and radiation m...
...d-stage laryngeal cancer constitutes a...
...nced Stage (T3, T4)...
...on surgery, combined chemotherapy and radia...
...ected patients with extensive T3 or large T4...
...should have multidisciplinary evaluati...
...ity of patients with T3, T4 primary-site disea...
...ncurrent chemoradiation therapy offe...
...is insufficient evidence to indicate...
...o desire larynx-preservation therapy but...
...onal Cervical Node...
...patients with T1, T2 lesions of the glot...
...dvanced lesions of the glottis and all patients...
...th clinically involved regional cervical...
...tients with equivocal fluorodeoxygluc...
...nts with clinically involved cervical nodes who...
...ient Selecti...
...ction of therapy for an individual patient r...
...validated markers that consistently p...
...igarette smoking is associated with a...