Laryngeal Cancer
Key Points
Key Points
For patients with locally advanced (T3, selected T4 or low volume T4) disease, organ-preservation surgery, combined chemotherapy and radiation, or radiation alone, offers the potential for larynx preservation without compromising overall survival.
For selected patients with extensive T3 or large T4a lesions and/or poor pretreatment laryngeal function, better survival rates and quality of life may
be achieved with total laryngectomy.
Patients with clinically involved regional cervical nodes (N+) who have a complete clinical and radiologic imaging response after chemoradiation
do not require elective neck dissection.
All patients should undergo a pretreatment, baseline assessment of voice and swallowing function and receive counseling regarding potential impact of treatment options on voice, swallowing, and quality of life.
Evaluation
Evaluati...
...rt of a comprehensive pretreatment evaluat...
...eatment voice and swallowing assessmen...
...performance status, and quality of...
Treatment
...reatment...
...Stage (T1, T2)...
...nts with T1, T2 laryngeal cancer should be tre...
...1, T2 laryngeal cancer can be treated with r...
...f the larynx preservation approach may be high...
...excision of the primary tumor with intent to...
...ocal tumor recurrence after radiation the...
...ombined chemotherapy and radiation may be used f...
...ted-stage laryngeal cancer constitu...
...vanced Stage (T3, T4)...
...preservation surgery, combined chemotherapy and ra...
...ed patients with extensive T3 or large...
...ients should have multidisciplinary eval...
...f patients with T3, T4 primary-site...
...ent chemoradiation therapy offers a significantly...
...ficient evidence to indicate that surviva...
...who desire larynx-preservation therapy but are no...
...egional Cervical...
...ts with T1, T2 lesions of the glottis...
...dvanced lesions of the glottis and a...
...h clinically involved regional cerv...
...equivocal fluorodeoxyglucose (18F-FDG...
...with clinically involved cervical nodes who ar...
...tient Selection...
...ection of therapy for an individual patient...
...re are no validated markers that consistently pred...
...cigarette smoking is associated with a worse out...