Laryngeal Cancer

Publication Date: November 27, 2017

Key Points

Key Points

Patients with T1, T2 laryngeal cancer should be treated initially with intent to preserve the larynx using endoscopic resection or radiation therapy, with either leading to similar outcomes.

For patients with locally advanced (T3, selected T4 or low volume T4) disease, organ-preservation surgery, combined chemotherapy and radiation, or radiation alone, offers the potential for larynx preservation without compromising overall survival.

For selected patients with extensive T3 or large T4a lesions and/or poor pretreatment laryngeal function, better survival rates and quality of life may
be achieved with total laryngectomy.

Patients with clinically involved regional cervical nodes (N+) who have a complete clinical and radiologic imaging response after chemoradiation
do not require elective neck dissection.

All patients should undergo a pretreatment, baseline assessment of voice and swallowing function and receive counseling regarding potential impact of treatment options on voice, swallowing, and quality of life.

Evaluation

Evaluati...

...t of a comprehensive pretreatment...


...tment voice and swallowing assessments should es...


...nstrumental, performance status, and quality...


Treatment

...eatment...

...d Stage (T1, T2...

...with T1, T2 laryngeal cancer shoul...

...al cancer can be treated with radia...

...ss of the larynx preservation approach...

...cision of the primary tumor with intent to...

...al tumor recurrence after radiation thera...

...bined chemotherapy and radiation may be used...

...tage laryngeal cancer constitutes a wide spec...


...nced Stage (T3, T4)...

...ation surgery, combined chemotherapy and radi...

...ted patients with extensive T3 or large...

All patients should have multidisciplinary eva...

...f patients with T3, T4 primary-site di...

...oncurrent chemoradiation therapy offers a s...

...fficient evidence to indicate that surviv...

For patients who desire larynx-preservation t...


...egional Cervical Node...

...nts with T1, T2 lesions of the glot...

...vanced lesions of the glottis and...

...tients with clinically involved region...

...atients with equivocal fluorodeoxyglucose (18F-...

...atients with clinically involved cervica...


...ent Selection...

...ion of therapy for an individual pa...

...lidated markers that consistently predic...

...arette smoking is associated with a worse outc...