Laryngeal Cancer
Key Points
Key Points
For patients with locally advanced (T3, selected T4 or low volume T4) disease, organ-preservation surgery, combined chemotherapy and radiation, or radiation alone, offers the potential for larynx preservation without compromising overall survival.
For selected patients with extensive T3 or large T4a lesions and/or poor pretreatment laryngeal function, better survival rates and quality of life may
be achieved with total laryngectomy.
Patients with clinically involved regional cervical nodes (N+) who have a complete clinical and radiologic imaging response after chemoradiation
do not require elective neck dissection.
All patients should undergo a pretreatment, baseline assessment of voice and swallowing function and receive counseling regarding potential impact of treatment options on voice, swallowing, and quality of life.
Evaluation
Evalua...
...a comprehensive pretreatment evaluation, all p...
...eatment voice and swallowing assessments should...
...umental, performance status, and quality of...
Treatment
...Limited Stag...
...with T1, T2 laryngeal cancer should be treate...
..., T2 laryngeal cancer can be treated with radiat...
...s of the larynx preservation approach may be h...
...excision of the primary tumor with intent to...
...ocal tumor recurrence after radiation...
...ned chemotherapy and radiation may...
...laryngeal cancer constitutes a wide spectr...
...Advanced...
...reservation surgery, combined chemotherapy and ra...
...patients with extensive T3 or large T4...
...tients should have multidisciplina...
...ty of patients with T3, T4 primary-site d...
...ncurrent chemoradiation therapy offers a significa...
...nsufficient evidence to indicate that...
...ho desire larynx-preservation therap...
...Regional...
...patients with T1, T2 lesions of the glottis an...
...ts with advanced lesions of the glott...
...atients with clinically involved regional cervica...
...with equivocal fluorodeoxyglucose (18F-F...
...nts with clinically involved cervical nodes w...
...erapy for an individual patient requires a...
...ere are no validated markers that consiste...
...inued cigarette smoking is associated...