Antiemetics
Key Points
Key Points
- The development of increasingly effective antiemetic regimens over the last quarter century has greatly reduced the incidence of nausea and vomiting due to chemotherapy.
- The recommended approach to preventing nausea and vomiting varies by the emetic risk of the treatment regimen.
- Adherence to antiemetic guidelines has been linked with improved control of nausea and vomiting.
- This update of the 2017 guideline adds guidance on the use of dexamethasone as a prophylactic antiemetic in patients receiving checkpoint inhibitors (CPIs).
Treatment
...Adult Patients...
...dult patients, the addition of a checkpo...
...High-Emetic-Risk Anti...
...dult patients treated with cisplatin and other h...
...reated with an anthracycline combined with cycloph...
...Moderate-Emeti...
...dult patients treated with carboplatin area under...
...treated with moderate-emetic-risk antineoplasti...
...treated with cyclophosphamide, doxorubicin,...
...Low-Emetic-Risk Ant...
...ients treated with low-emetic-risk ant...
...Minimal Emetic Risk An...
...tients treated with minimal emetic risk antineop...
...Anti...
...dult patients treated with antineoplastic comb...
...Adjunctive Drugs...
Lorazepam is a useful adjunct to antiemetic drugs,...
...Cannabinoids...
...dence remains insufficient for a recommendation...
...Complementary...
...s insufficient for a recommendation for...
...High-...
...treated with high-dose chemotherapy and st...
...ur-drug combination of an NK1 receptor antagonist,...
...Multid...
...t patients treated with multiday antineop...
...patients treated with 4- or 5-day cisp...
...Breakt...
...nts with breakthrough nausea or vo...
...atients who experience nausea or vomiting despit...
...nol and nabilone ( IC , I , M )6539...
...ise ( IC , L , M )65...
...Anticipatory...
...tients should receive the most act...
...High Emetic Risk...
...ult patients treated with high-emetic-...
...Moder...
...dult patients treated with moderate-emetic-risk r...
...Low E...
...lt patients treated with radiation therapy...
...Minimal Emetic Risk Radia...
...lt patients treated with minimal emetic risk...
...Co...
...ult patients treated with concurrent radia...
...Pediatric Patients...
...High Emetic R...
...Pediatric patients treated with high-emetic-ri...
...ated) Pediatric patients treated with...
...iatric patients treated with high-eme...
Mo...
...tients treated with moderate-emetic-risk a...
...) Pediatric patients treated with moderat...
...Low Emetic Risk Antin...
...ients treated with low-emetic-risk antineo...
...Mini...
...tric patients treated with minimal emetic risk an...
...Emetic Risk of Single Intravenous Antineo...
.... Emetic Risk of Single Oral Antineoplas...
Table 3. Antiemetic Dosing for Adults by Ch...
...metic Risk in Adults by Site of Radiation Th...
...emetic Administration in Adults by Radiation Ther...