Cervical Cancer Prevention

Publication Date: March 17, 2017

Key Points

Key Points

Vaccination is the optimal strategy for primary prevention of infection by some types of human papillomavirus that cause cervical cancer in the target population. There is no other preventive strategy for this cancer that can substitute for vaccination.

There are three prophylactic HPV vaccines approved and recommended in the United States, Europe, and many regions and countries: the bivalent (2vHPV; against HPV 16 and 18), quadrivalent (4vHPV; against HPV 6, 11, 16, and 18), and nine valent (9vHPV; against HPV 6, 11, 16, 18, 31, 33, 45, 52 and 58)

NOTE: Gardasil-9 (9-valent HPV vaccine) will be the only HPV vaccine available in the United States after May 2017.
Source: https://www.cdc.gov/vaccines/hcp/vis/vis-statements/hpv.html.

As a partial result of failures within different health care systems at both levels of prevention—vaccination, screening—and disease treatment/management, there are large regional and global disparities in cervical cancer incidence and mortality. Consequently ASCO has established a process for resource-stratified guidelines.

Prevention

...Prevention...

...esource Stratification: Primary Preve...


In Maximal And Enhanced Resource Settings

In Max...

...h authorities, ministries of health, and prima...


...ealth authorities may set the upper end of the tar...


...or girls 9–14 years of age who ar...


...months ( EB , H , S )614...

...o 12–15 months (EB, L, W)614...


Girls ≥15 years of age at the time...


...les who have received one dose and are >14...


...revention of cervical cancer, if there...


...ion of cervical cancer in maximal or en...


In Limited Resource Settings

...In Limi...

...c health authorities, ministries of health, and...


...rting at 9 years of age who are immune compete...


...onths ( EB , H , S )614...

...p to 12–15 months ( EB , L ,...


If there are sufficient resources re...


...prevention of cervical cancer in limited...


In Basic Settings

...In Basic Settings...

...ublic health authorities, ministries of health, an...


...rls starting at 9 years of age who...


...6 months ( EB , H , S )614...

...to 12–15 months. ( EB , L , M...


...igh coverage of priority populations sh...


...revention of cervical cancer in basic re...


In All Resource Settings

...In All Resource...

...s who are HIV positive or immunosup...


...is NOT recommended for pregnant wom...


...ccination strategy is recommended f...