Cervical Cancer Prevention

Publication Date: March 17, 2017

Key Points

Key Points

Vaccination is the optimal strategy for primary prevention of infection by some types of human papillomavirus that cause cervical cancer in the target population. There is no other preventive strategy for this cancer that can substitute for vaccination.

There are three prophylactic HPV vaccines approved and recommended in the United States, Europe, and many regions and countries: the bivalent (2vHPV; against HPV 16 and 18), quadrivalent (4vHPV; against HPV 6, 11, 16, and 18), and nine valent (9vHPV; against HPV 6, 11, 16, 18, 31, 33, 45, 52 and 58)

NOTE: Gardasil-9 (9-valent HPV vaccine) will be the only HPV vaccine available in the United States after May 2017.
Source: https://www.cdc.gov/vaccines/hcp/vis/vis-statements/hpv.html.

As a partial result of failures within different health care systems at both levels of prevention—vaccination, screening—and disease treatment/management, there are large regional and global disparities in cervical cancer incidence and mortality. Consequently ASCO has established a process for resource-stratified guidelines.

Prevention

...Prevention...

...of Resource Stratification: Primary Prevent...


In Maximal And Enhanced Resource Settings

...In Maximal And Enhan...

...uthorities, ministries of health, and prima...


...ealth authorities may set the upper end of th...


...14 years of age who are immune competent...


...st 6 months ( EB , H , S )614

...y be up to 12–15 months (EB, L,...


...≥15 years of age at the time of t...


...have received one dose and are >1...


...ion of cervical cancer, if there is low...


...prevention of cervical cancer in maximal...


In Limited Resource Settings

...In Limited...

...thorities, ministries of health, and prima...


...rting at 9 years of age who are immune compe...


...months ( EB , H , S )614...

...12–15 months ( EB , L , M )614...


...e are sufficient resources remaining after vaccina...


...of cervical cancer in limited resource set...


In Basic Settings

...In Basic Set...

...ublic health authorities, ministries of healt...


...starting at 9 years of age who are immune c...


...onths ( EB , H , S )614...

...ay be up to 12–15 months. ( EB ,...


...rage of priority populations should be emph...


...evention of cervical cancer in basic resour...


In All Resource Settings

...In...

...who are HIV positive or immunosuppr...


...tion is NOT recommended for pregnant...


...vaccination strategy is recommended for women re...