Cervical Cancer Prevention

Publication Date: March 17, 2017

Key Points

Key Points

Vaccination is the optimal strategy for primary prevention of infection by some types of human papillomavirus that cause cervical cancer in the target population. There is no other preventive strategy for this cancer that can substitute for vaccination.

There are three prophylactic HPV vaccines approved and recommended in the United States, Europe, and many regions and countries: the bivalent (2vHPV; against HPV 16 and 18), quadrivalent (4vHPV; against HPV 6, 11, 16, and 18), and nine valent (9vHPV; against HPV 6, 11, 16, 18, 31, 33, 45, 52 and 58)

NOTE: Gardasil-9 (9-valent HPV vaccine) will be the only HPV vaccine available in the United States after May 2017.
Source: https://www.cdc.gov/vaccines/hcp/vis/vis-statements/hpv.html.

As a partial result of failures within different health care systems at both levels of prevention—vaccination, screening—and disease treatment/management, there are large regional and global disparities in cervical cancer incidence and mortality. Consequently ASCO has established a process for resource-stratified guidelines.

Prevention

...vention...

Framework of Resource Stratificatio...


In Maximal And Enhanced Resource Settings

...And Enhanced Resource Settings...

...health authorities, ministries of heal...


...health authorities may set the upper...


...“14 years of age who are immune co...


...ast 6 months ( EB , H , S...

...12–15 months (EB, L, W)614...


...rls ≥15 years of age at the time o...


...o have received one dose and are >14 years of...


...vention of cervical cancer, if there is lo...


...ntion of cervical cancer in maxima...


In Limited Resource Settings

...ed Resource Settings...

...th authorities, ministries of healt...


...or girls starting at 9 years of age who ar...


...t least 6 months ( EB , H ,...

...12–15 months ( EB , L , M )614


...there are sufficient resources remaining aft...


...tion of cervical cancer in limited resource...


In Basic Settings

...Basic Settings...

...lic health authorities, ministries o...


...girls starting at 9 years of age who a...


...t least 6 months ( EB , H , S )614...

...y be up to 12–15 months. ( EB , L , M...


...of priority populations should be emphasized....


...n of cervical cancer in basic resource setti...


In All Resource Settings

...esource Settings...

...who are HIV positive or immunosuppressed...


...accination is NOT recommended for pregna...


...strategy is recommended for women receiving t...