White Blood Cell Growth Factors

Publication Date: July 21, 2015

Key Points

Key Points

Prophylactic use of colony-stimulating factors (CSFs) to reduce the risk of febrile neutropenia is warranted when the risk of febrile neutropenia is approximately 20% or higher and no other equally effective and safe regimen that does not require CSFs is available.

Primary prophylaxis is recommended for the prevention of febrile neutropenia in patients who are at high risk on the basis of age, medical history, disease characteristics, and myelotoxicity of the chemotherapy regimen.

Dose-dense regimens that require CSFs should be used only within an appropriately designed clinical trial or if supported by convincing efficacy data.

Current recommendations for the management of patients exposed to lethal doses of total-body radiotherapy, but not doses high enough to lead to certain death as a result of injury to other organs, include the prompt administration of CSFs.

Diagnosis

...gnosis

...atient Risk Factors for Febrile Neutropenia ...


...e 2. Patient Risk Factors for Poor Clini...


Treatment for Adult Patients

...reatment for Adult Patients...

...ry prophylaxis with a CSF starting with the f...


...ndary prophylaxis with a CSF is recommended...


...SFs should not be routinely used for patients...


...should not be routinely used as adjunctive treatm...


...cancer and lymphoma] ( EB , H , B...

...r urothelial cancer] ( EB , H , H , M )3336...


...d alone, after chemotherapy, or in co...


...administered after autologous stem-cell transplan...


...Fs may be administered after allogeneic stem-cel...


...c CSFs for patients with diffuse aggr...


...filgrastim, tbo-filgrastim, and fil...


...t recommendations for the management of...


Treatment for Pediatric Patients

...atment for Pediatric P...

...CSFs in pediatric patients will almost always be...


...pediatric indications in which dose...


...SFs should not be used in pediatric...


Table 3. Dosing and Administration of CSFs

...able 3. Dosing and Administration of CSFsH...