Cardiac Dysfunction - Prevention and Monitoring in Cancer Survivors

Publication Date: December 5, 2016

Key Points

Key Points

Cardiac dysfunction is a serious side effect of certain cancer-directed therapies that can interfere with the efficacy of treatment, decrease quality of life, or impact the actual survival of the cancer patient.

Heart failure (HF), presenting during or after completion of cancer treatment, is a well-recognized complication that begins with risk factors known to be associated with the development of HF, including the toxicity of chemotherapy and/or radiation (stage A), and is commonly progressive after structural changes to the heart occur.

The initial manifestation may be asymptomatic.

Onset may also be responsible for interruption or discontinuation of cancer-directed therapy, potentially reducing the chance for long-term survival.

Risk

Risk

...t is recommended that cancer patients who meet an...


...recommendation can be made on the r...


Prevention

...evention...

...evention PRIOR TO Initiation of Therap...

...or minimize the use of potentially cardio...

Clinicians should perform a comprehensive...


...ING Potentially Cardiotoxic Cancer The...

...s should screen for and actively manage modifiabl...

...cians may incorporate a number of strate...

...r patients who require mediastinal...


Surveillance

...urveillanc...

...ring During Treatment...

...s should complete a careful history and ph...

...ecommendation 4....

...rdiogram for diagnostic work-up ( EB , H...

...ic resonance imaging (MRI) or multi-gated acquisit...

...cardiac biomarkers (troponins, natriure...

...l to a cardiologist based on findings. (EB, B,...

...ne surveillance imaging may be offered during tr...

...mmendations can be made regarding...

...ans may use routine echocardiographic...


...nitoring After Treat...

...should complete a careful history and...

...ecommendation 5....

...cardiogram for diagnostic work-up ( EB , H...

Cardiac MRI or MUGA if echocardiogram i...

...c biomarkers (troponins, natriuretic peptides)...

...ral to a cardiologist based on finding...

...am may be performed 6–12 months after...

...ardiac MRI or MUGA may be offered for surveillanc...

...ntified to have asymptomatic cardiac dys...

...ations can be made regarding the frequency...

...should regularly evaluate and man...