Mature Oocyte Cryopreservation

Publication Date: January 1, 2013
Last Updated: March 14, 2022


In patients facing infertility due to chemotherapy or other gonadotoxic therapies, oocyte cryopreservation is recommended with appropriate counseling. (, B)

More widespread clinic-specific data on the safety and efficacy of oocyte cryopreservation in donor populations are needed before universal donor oocyte banking can be recommended. (, B)

There are not yet sufficient data to recommend oocyte cryopreservation for the sole purpose of circumventing reproductive aging in healthy women. (, B)

More data are needed before this technology should be used routinely in lieu of embryo cryopreservation. (, B)

Recommendation Grading




Mature Oocyte Cryopreservation

Authoring Organization

Publication Month/Year

January 1, 2013

Last Updated Month/Year

August 22, 2023

Supplemental Implementation Tools

Document Type


External Publication Status


Country of Publication


Document Objectives

There is good evidence that fertilization and pregnancy rates are similar to IVF/ICSI with fresh oocytes when vitrified/warmed oocytes are used as part of IVF/ICSI for young women. Although data are limited, no increase in chromosomal abnormalities, birth defects, and developmental deficits has been reported in the offspring born from cryopreserved oocytes when compared to pregnancies from conventional IVF/ICSI and the general population. Evidence indicates that oocyte vitrification and warming should no longer be considered experimental. This document replaces the document last published in 2008 titled, “Ovarian Tissue and Oocyte Cryopreservation,” Fertil Steril 2008;90:S241-6.

Inclusion Criteria

Female, Adult

Health Care Settings

Ambulatory, Laboratory services, Outpatient

Intended Users

Nurse, nurse practitioner, physician, physician assistant


Counseling, Assessment and screening, Management

Diseases/Conditions (MeSH)

D007246 - Infertility, D007247 - Infertility, Female, D059471 - In Vitro Oocyte Maturation Techniques, D054315 - Oocyte Retrieval


infertility, crylopreservation

Source Citation

Mature oocyte cryopreservation: a guideline
Fertility and Sterility, Volume 99, Issue 1, 37 - 43