Adenovirus In Solid Organ Transplant Recipients

Surveillance testing for adenovirus should not be performed in asymptomatic SOT recipients. (Low, Strong)

Detection of adenovirus by culture or PCR testing should be correlated with clinical symptoms, detection of the virus from other sites, and histopathologic findings to establish whether disease is present. (Low, Strong)

Testing of serial quantitative PCR may assist in the decision to initiate therapy and in monitoring response to therapy as there is not an established threshold value at which to start therapy. (Low, Weak)

Histopathologic analysis of biopsy samples demonstrating evidence of adenovirus disease remains the gold standard for diagnosis. (High, Strong)

PCR‐based testing on blood, stool, or respiratory secretions, as appropriate, should be used to detect adenovirus when histopathologic diagnosis is not possible. (Moderate, Strong)

Assessment of a patient's adenovirus‐specific immune response may help gauge the need for adenovirus therapy in the future. (, )