Human Parvovirus B19 In Solid Organ Transplantation

Parvovirus B19 infection should be suspected in SOT recipients with:

• Anemia with inappropriate reticulocyte response or erythro‐ poietin‐resistant anemia with or without:
• Fever, arthralgia, or rash
• Organ‐invasive diseases such as hepatitis, myocarditis, pneu‐ monitis, neurological disease, or vasculitis
• Pancytopenia

(Moderate, Strong)

The initial work‐up for suspected parvovirus B19 infection should include IgG and IgM serology (Low, Strong)

Bone marrow examination should be performed when parvovirus B19 infection is strongly suspected, and the serology and serum PCR are negative. In addition, in situ hybridization or immunohistochemical staining should be performed. (Moderate, Strong)