Margins For Breast-Conserving Surgery With Whole-Breast Irradiation In Stages I And II Invasive Breast Cancer

Publication Date: March 1, 2014
Last Updated: March 14, 2022

Guideline Recommendations

What is the absolute increase in risk of IBTR with a positive margin? Can the use of radiation boost, systemic therapy, or favorable tumor biology mitigate this increased risk?

Positive margins, defined as ink on invasive cancer or DCIS, are associated with at least a 2-fold increase in IBTR. This increased risk in IBTR is not nullified by: delivery of a boost, delivery of systemic therapy (endocrine therapy, chemotherapy, biologic therapy), or favorable biology.
(Level of evidence: Meta-analysis and secondary data from prospective trials and retrospective studies)
6731

Overview

Title

Margins For Breast-Conserving Surgery With Whole-Breast Irradiation In Stages I And II Invasive Breast Cancer

Authoring Organizations