Last updated March 15, 2022

Diagnosis And Treatment Of Bronchial Intraepithelial Neoplasia And Early Lung Cancer Of The Central Airways: Diagnosis And Management Of Lung Cancer

Recommendations

Proposed Indications for white light bronchoscopy (WLB) and autofluorescence bronchoscopy (AFB)

In patients with severe dysplasia or CIS in sputum cytology who have chest imaging studies showing no localizing abnormality, standard WLB is suggested to exclude an endobronchial lesion. (2, C)
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For patients with known severe dysplasia or CIS in the central airways on biopsy, follow-up WLB is suggested. (2, C)
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For patients with early lung cancer undergoing resection, WLB is suggested for the delineation of tumor margins and the assessment of synchronous lesions. (2, C)
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For patients being considered for curative endobronchial therapy to treat CIS or early central lung cancer, WLB is suggested over routine use of AFB. (2, C)
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Techniques of Endobronchial Therapy

For patients with superficial limited mucosal lung cancer in the central airway who are not candidates for surgical resection, endobronchial treatment with PDT, brachytherapy, cryotherapy, or electrocautery is recommended. (1, C)
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Recommendation Grading

Overview

Title

Diagnosis And Treatment Of Bronchial Intraepithelial Neoplasia And Early Lung Cancer Of The Central Airways: Diagnosis And Management Of Lung Cancer

Authoring Organization

Publication Month/Year

May 1, 2013

Document Type

Guideline

External Publication Status

Published

Country of Publication

US

Document Objectives

Bronchial intraepithelial lesions may be precursors of central airway lung carcinomas. Identification and early treatment of these preinvasive lesions might prevent progression to invasive carcinoma.

Target Patient Population

Patients with lung cancer

Inclusion Criteria

Female, Male, Adolescent, Adult, Older adult

Health Care Settings

Ambulatory, Hospital, Long term care, Operating and recovery room, Outpatient

Intended Users

Nurse, nurse practitioner, physician, physician assistant

Scope

Diagnosis, Prevention, Management, Treatment

Diseases/Conditions (MeSH)

D000081483 - Squamous Intraepithelial Lesions, D001984 - Bronchial Neoplasms

Keywords

lung cancer, early treatment, invasive carcinoma