Treatment Of Stage IV Non-Small Cell Lung Cancer: Diagnosis And Management Of Lung Cancer

In patients with a good PS (ie, ECOG level 0 or 1) and stage IV NSCLC, a platinum-based chemotherapy regimen is recommended based on the survival advantage and improvement in QOL over BSC. (1, A)

In patients with stage IV NSCLC and a good PS, two-drug combination chemotherapy is recommended. The addition of a third cytotoxic chemotherapeutic agent is not recommended because it provides no survival benefit and may be harmful. (1, A)