Perioperative Management Of Antithrombotic Therapy
Publication Date: August 11, 2022
Summary of Key Recommendations
In patients receiving VKA therapy for a mechanical heart valve who require VKA interruption for an elective surgery/procedure, we suggest against heparin bridging. (C, VL)
620
In patients receiving VKA therapy for atrial fibrillation who require VKA interruption for an elective surgery/procedure, we recommend against heparin bridging. (S, M)
620
In patients receiving VKA therapy for VTE as the sole clinical indication who require VKA interruption for an elective surgery/procedure, we suggest against heparin bridging. (C, VL)
620
In patients receiving VKA therapy who require a pacemaker or ICD implantation, we recommend continuation of VKA over VKA interruption and heparin bridging. (S, M)
620
In patients receiving VKA therapy who require VKA interruption for a colonoscopy with anticipated polypectomy, we suggest against heparin bridging during the period of VKA interruption. (C, VL)
620
In patients receiving LMWH bridging for an elective surgery/procedure, we suggest against routine measurement of anti-factor Xa levels to guide perioperative LMWH management. (C, VL)
620
In patients receiving apixaban who require an elective surgery/procedure, we suggest stopping apixaban for 1-2 days, before the surgery/procedure over apixaban continuation. (C, VL)
620
In patients receiving dabigatran who require an elective surgery/procedure, we suggest stopping dabigatran for 1-4 days before the surgery/procedure over dabigatran continuation. (C, VL)
620
In patients receiving edoxaban who require an elective surgery/procedure, we suggest stopping edoxaban for 1-2 days before the surgery/procedure over edoxaban continuation. (C, VL)
620
In patients receiving rivaroxaban who require an elective surgery/procedure, we suggest stopping rivaroxaban for 1-2 days before the surgery/procedure over rivaroxaban continuation. (C, VL)
620
In patients who require DOAC interruption for an elective surgery/procedure, we suggest against perioperative heparin bridging. (C, VL)
620
In patients who had DOAC interruption for an elective surgery/procedure, we suggest resuming DOACs >24 hours after a surgery/procedure over resuming DOACs within 24 hours. (C, VL)
620
In patients who had DOAC interruption for an elective surgery/procedure, we suggest against routine DOAC coagulation function testing to guide perioperative DOAC management. (C, VL)
620
In patients receiving ASA who are undergoing elective non-cardiac surgery, we suggest ASA continuation over ASA interruption. (C, M)
620
In patients who are receiving ASA and undergoing CABG surgery, we suggest continuation of ASA over interruption; in patients receiving a P2Y12 inhibitor drug, we suggest interruption of the P2Y12 inhibitor over continuation peri-operatively. (C, L)
620
In patients receiving antiplatelet drug therapy who are undergoing an elective surgery/procedure, we suggest against the routine use of platelet function testing prior to the surgery/procedure to guide perioperative antiplatelet management. (C, VL)
620
In patients receiving ASA and a P2Y12 inhibitor who had coronary stents placed within the last 3-12 months and are undergoing an elective surgery/procedure, we suggest stopping the P2Y12 inhibitor prior to surgery over continuation of the P2Y12 inhibitor. (C, VL)
620
In patients with coronary stents who require interruption of antiplatelet drugs for an elective surgery/procedure, we suggest against routine bridging therapy with a glycoprotein IIb-IIIa inhibitor, cangrelor, or LMWH over routine use of bridging therapy. (C, L)
620
- ASA: Acetylsalicylic Acid
- CABG: Coronary Artery Bypass Graft
- DOAC: Direct Oral Anticoagulants
- LMWH: Low Molecular Weight Heparin
- UFH: Unfractionated Heparin
- VKA: Vitamin K Antagonist
- VTE: Venous Thromboembolism
- aPTT: Activated Partial Thromboplastin Time
Title
Perioperative Management Of Antithrombotic Therapy
Authoring Organization
American College of Chest Physicians
Publication Month/Year
August 11, 2022
External Publication Status
Published
Country of Publication
US
Document Objectives
This guideline addresses the management of patients who are receiving anticoagulant or antiplatelet therapy and require an elective surgery or procedure.
Target Patient Population
Patients receiving anticoagulant or antiplatelet therapy and require an elective surgery or procedure
Inclusion Criteria
Male, Female, Adolescent, Adult, Older adult
Health Care Settings
Emergency care, Hospital, Long term care, Outpatient, Operating and recovery room
Intended Users
Nurse, nurse practitioner, physician, physician assistant
Scope
Assessment and screening, Treatment, Management, Prevention
Diseases/Conditions (MeSH)
D000925 - Anticoagulants, D013502 - General Surgery, D000079645 - Perioperative Medicine, D019990 - Perioperative Care
Keywords
anticoagulation, surgery, perioperative, perioperative care, Antithrombotic Agents, Anticoagulation
Methodology
Number of Source Documents
295
Literature Search Start Date
December 1, 2011
Literature Search End Date
July 1, 2021